Results 121 to 130 of about 271,229 (377)

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer [PDF]

, 2014
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis.
Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abhik Mukherjee, Ajit Jadhav, Anton Simeonov, Bergh, Brown, Buterin, Carlos Caldas, Chin, Curtis, David J. Maloney, David M. Wilson, Devika Agarwal, Dorjbal Dorjsuren, Dorjsuren, Graham Ball, Guo, Henneke, Henneke, Hongmao Sun, Hothorn, Ian O. Ellis, Jennifer L. Illuzzi, Kim, Kim, Krause, Kucherlapati, Kucherlapati, Lam, Larsen, Larsen, Liu, McShane, Moggs, Nada Albarakati, Nikolova, Oscar M. Rueda, Paul Moseley, Pawitan, Rachel Abbotts, Roslin Russell, Sato, Schultz-Norton, Shen, Singh, Srinivasan Madhusudan, Stephen Chan, Sultana, Tarek M.A. Abdel-Fatah, van Pel, Vivek Mohan, Wu, Xu, Yang, Zheng, Zheng   +59 more
core   +2 more sources

Conserved Endonuclease Function of Hantavirus L Polymerase

Viruses, 2016
Hantaviruses are important emerging pathogens belonging to the Bunyaviridae family. Like other segmented negative strand RNA viruses, the RNA-dependent RNA polymerase (RdRp) also known as L protein of hantaviruses lacks an intrinsic “capping activity ...
Sylvia Rothenberger, Giulia Torriani, Maria U. Johansson, Stefan Kunz, Olivier Engler   +4 more
doaj   +1 more source

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

DNA binding shifts the redox potential of the transcription factor SoxR [PDF]

, 2008
Electrochemistry measurements on DNA-modified electrodes are used to probe the effects of binding to DNA on the redox potential of SoxR, a transcription factor that contains a [2Fe-2S] cluster and is activated through oxidation. A DNA-bound potential of +
A. A. Gorodetsky, Ansari, B. Demple, Beinert, Boal, Boon, Boon, Brown, Carter, Changela, D. K. Newman, Demple, Dietrich, Ding, Fromme, Fu, Gaudu, Giancarlo, Gorodetsky, Gorodetsky, Gorodetsky, Ha, Heldwein, Hidalgo, Hidalgo, Hidalgo, Hidalgo, Hobman, Hwang, J. K. Barton, Kobayashi, Kobayashi, Koo, Kuo, L. E. P. Dietrich, Liochev, Liochev, Okamoto, Outten, P. E. Lee, Park, Pomposiello, Pomposiello, Price-Whelan, Stephens, Stover, Thayer, Udit, Zheng   +48 more
core   +2 more sources

The Molecular Perspective: Restriction Endonucleases [PDF]

STEM CELLS, 2002
The Oncologist 2002;7:82-83 www.TheOncologist.com We live in a remarkable age. Physicians now have an unprecedented range of options for helping their patients. Surgery and radiology are using advanced technologies to pinpoint treatments. Chemotherapeutic approaches are showing ever-greater effectiveness and specificity, approaching the goal of a ...
openaire   +4 more sources

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity*

Journal of Biological Chemistry, 2014
Background: DNA-PKcs stimulates the endonucleolytic activities of ARTEMIS but not the 5′-exonuclease activity. Results: Point mutagenesis, small molecule inhibitors, and modulation of divalent cation concentrations all affect both the endonuclease and 5′-
Sicong Li, Howard H. Y. Chang, D. Niewolik, M. Hedrick, A. Pinkerton, C. Hassig, K. Schwarz, M. Lieber   +7 more
semanticscholar   +1 more source

Electrochemical DNA Cleavage Sensing for EcoRV Activity and Inhibition with an ERGO Electrode

Biosensors
An electrochemically reduced graphene oxide (ERGO) electrode-based electrochemical assay was developed for rapid, sensitive, and straightforward analysis of both activity and inhibition of the endonuclease EcoRV.
Da Eun Oh, Hyun Beom Kim, Tae Hyun Kim
doaj   +1 more source

Chapter 9 Gene Drive Strategies for Population Replacement [PDF]

, 2016
Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to ...
Akbari, Omar S, Marshall, John M
core   +1 more source

Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria

Nucleic Acids Research, 1995
Two Mg(2+)-dependent DNA endonucleases have been isolated from mammalian cells which have a strong preference to nick within long tracts of guanine residues in vitro. One endonuclease activity is mitochondrial (mt). The other endonuclease, called Endonuclease G, is associated with isolated nuclei, and is released when the nuclear chromatin is exposed ...
Mariana Gerschenson, Kathryn L. Houmiel, Robert L. Low   +2 more
openaire   +3 more sources

Toward establishing a rapid constant temperature detection method for canine parvovirus based on endonuclease activities

Microbiology Spectrum
Canine parvovirus (CPV) can cause high morbidity and mortality rates in puppies, posing a significant threat to both pet dogs and the breeding industry.
Shaoting Weng, Shengming Ma, Yueteng Xing, Wenhui Zhang, Yinrong Wu, Mengyao Fu, Zhongyi Luo, Qiuying Li, Sen Lin, Longfei Zhang, Yao Wang   +10 more
doaj   +1 more source