Results 181 to 190 of about 299,455 (330)

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Contrasting roles of APE1 and APE2 in genome maintenance, cancer development, and therapeutic targeting. [PDF]

NAR Cancer
Sharma A, Grimsley HE, Courtemanche K, Powell SN.   +3 more
europepmc   +1 more source

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Nature Biotechnology, 2014
Xuebing Wu, David A. Scott, Andrea J. Kriz, Anthony C Chiu, P. Hsu, D. Dadon, A. Cheng, Alexandro E. Trevino, S. Konermann, Sidi Chen, R. Jaenisch, Feng Zhang, P. Sharp   +12 more
semanticscholar   +1 more source

Evolution of a phage RuvC endonuclease for resolution of both Holliday and branched DNA junctions [PDF]

, 2005
Fiona A. Curtis, Patricia Reed, Gary J. Sharples   +2 more
openalex   +1 more source

Unusual Disease‐Progression in Two Siblings With Xeroderma Pigmentosum Group G

Clinical Genetics, EarlyView.
Protein truncation mutations in the gene for XPG nuclease cause a very severe clinical phenotype. Two siblings have splicing mutations, which result in in‐frame deletions and a less severe phenotype.
Elena Botta, Heather Fawcett, Donata Orioli, Hiva Fassihi, Alan R. Lehmann   +4 more
wiley   +1 more source

DNA mismatch repair mediated by Mlh1-Pms1 endonuclease-catalyzed mispair excision. [PDF]

Proc Natl Acad Sci U S A
Palacio T, Calil FA, Bowen N, Griffith JD, Putnam CD, Kolodner RD.   +5 more
europepmc   +1 more source

Endonuclease V of Escherichia coli.

, 1977
F T Gates, Stuart Linn
openalex   +1 more source

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

Molecular characterisation of Toxoplasma gondii Mre11 reveals unique structural features and potential as a therapeutic target. [PDF]

Sci Rep
Ruiz DM, Turowski VR, Sullivan WJ, Angel SO.   +3 more
europepmc   +1 more source

PHYLOGENETIC INFERENCE FROM RESTRICTION ENDONUCLEASE CLEAVAGE SITE MAPS WITH PARTICULAR REFERENCE TO THE EVOLUTION OF HUMANS AND THE APES

Evolution; international journal of organic evolution, 1983
Alan R. Templeton
semanticscholar   +1 more source