Results 291 to 300 of about 299,455 (330)

Human APE2 and TREX2 Repair 3'-DNA-Peptide Cross-links Derived from Abasic Sites. [PDF]

Chem Res Toxicol
Wei X, Cepeda J, Chung JM, Lee SE, Yang K.   +4 more
europepmc   +1 more source

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez, Isabel Sierra, Jop Kind   +2 more
wiley   +1 more source

Continuous secretory production in E. coli enables scalable, high-titer manufacturing of active recombinant endonucleases. [PDF]

J Biol Eng
Lokireddy SR, Thummadhi C, Godavarty P, Petla V, Munimanda A, Kunchala SR, Vadde R.   +6 more
europepmc   +1 more source

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase

Deng A, Cunnison R, Carrique L, Günl F, Paddon E, Staeyart J, Duc DN, Grimes JM, Robb N, Keown JR.   +9 more
europepmc   +1 more source

Determining the Presence of a Polymorphism in the Calpastatin (<i>CAST</i>) Gene Locus and Its Influence on Some Fattening Traits in Danube White Pigs. [PDF]

Life (Basel)
Eneva K, Stoykova-Grigorova R, Yordanova G, Petrova M, Nedeva R, Penchev I, Penev T.   +6 more
europepmc   +1 more source

Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications

Advanced Materials, Volume 38, Issue 2, 8 January 2026.
Vasculature is indispensable for tissue viability in regenerative medicine. The sacrificial biofabrication enables precise fabrication of vascular channels by using temporary templates that are subsequently removed. This review defines the concept and delves into sacrificial materials, surrounding materials, fabrication technologies, and biomedical ...
Jiezhong Shi, Chunyao Wang, Xuan Mei, Ben Zhang, Junxi Wu, Rylie A. Green, Yu Shrike Zhang, Wenmiao Shu   +7 more
wiley   +1 more source

Dirty Ends: Formation, Repair, and Biological Relevance of Non-Canonical DNA Terminal Structures. [PDF]

Genes (Basel)
Sothy S, Zhao L.
europepmc   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

KHNYN is a manganese-dependent endoribonuclease required for ZAP-mediated antiviral restriction. [PDF]

Nucleic Acids Res
Youle RL, Lista MJ, Brudenell EL, Thompson B, Bouton C, Morris ER, Neil SJD, Swanson CM, Taylor IA.   +8 more
europepmc   +1 more source