Results 31 to 40 of about 626 (166)

Current management of uveal melanoma: A review

Clinical &Experimental Ophthalmology, Volume 51, Issue 5, Page 484-494, July 2023., 2023
Abstract Uveal melanoma is the most frequent primary intraocular cancer in adulthood and is mostly localised to the choroid. It can be treated using radiation therapy, laser therapy, local resection and enucleation, with the best results achieved by combining these procedures. However, up to half of patients develop metastatic disease.
Haixia Bai, Jacobus J. Bosch, Ludwig M. Heindl   +2 more
wiley   +1 more source

Fractionated stereotactic radiotherapy for uveal melanoma: Long‐term outcome and control rates

Acta Ophthalmologica, Volume 100, Issue 5, Page 511-519, August 2022., 2022
Abstract Purpose The aim of our study is to evaluate local tumour control rates, radiation side‐effects, visual preservation and disease‐free survival (DFS) of uveal melanoma (UM) patients treated with fractionated stereotactic radiotherapy (fSRT). Methods A retrospective study of UM patients, who were treated with fSRT (N = 189), was performed by the ...
Jackelien G. M. van Beek, Caroline M. van Rij, Sara J. Baart, Serdar Yavuzyigitoglu, Michael J. Bergmann, Dion Paridaens, Nicole C. Naus, Emine Kiliç   +7 more
wiley   +1 more source

Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

The Journal of Pathology: Clinical Research, Volume 8, Issue 4, Page 383-394, July 2022., 2022
Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3). Advances in understanding UM cell biology may indicate new therapeutic options.
Dorota Sabat‐Pośpiech, Kim Fabian‐Kolpanowicz, Helen Kalirai, Natalie Kipling, Sarah E Coupland, Judy M Coulson, Andrew B Fielding   +6 more
wiley   +1 more source

Psychosocial impact of prognostic genetic testing in the care of uveal melanoma patients: protocol of a controlled prospective clinical observational study [PDF]

, 2016
Background: Uveal melanoma patients with a poor prognosis can be detected through genetic analysis of the tumor, which has a very high sensitivity. A large number of patients with uveal melanoma decide to receive information about their individual risk
Anja Breidenstein, Claudia HD Metz, Dietmar Lohmann, Hans-Christoph Friederich, Jennifer Scheel, Sefik Tagay, Yesim Erim   +6 more
core   +3 more sources

Efficacy and safety of current treatment options for peripheral retinal haemangioblastomas: a systematic review

Acta Ophthalmologica, Volume 100, Issue 1, Page e38-e46, February 2022., 2022
Abstract Importance Approximately twenty per cent of Von Hippel–Lindau patients with retinal haemangioblastomas (RH) suffer from visual impairment. Various treatment options are available for peripheral RH. However, management of peripheral RH is complex due to multifocality and bilaterality.
Anass Hajjaj, Koen A. van Overdam, Olta Gishti, Wishal D. Ramdas, Emine Kiliç   +4 more
wiley   +1 more source

Early detection of metastatic uveal melanoma by the analysis of tumor‐specific mutations in cell‐free plasma DNA

Cancer Medicine, Volume 10, Issue 17, Page 5974-5982, September 2021., 2021
In metastasized uveal melanoma (UM) patients, circulating tumor DNA (ctDNA) can be detected in blood. Here we explored if cfDNA is a suitable biomarker for the early detection of metastatic disease in UM patients. Our data show that this biomarker fulfills the expectation as, overall, about half of the patients who developed metastases showed a ...
Claudia H. D. Le Guin, Norbert Bornfeld, Nikolaos E. Bechrakis, Leyla Jabbarli, Heike Richly, Dietmar R. Lohmann, Michael Zeschnigk   +6 more
wiley   +1 more source

Radiation treatment methods in uveal melanoma [PDF]

, 2021
Background: The most frequent primary ocular malignancy in the western world is the uveal melanoma. While it mainly affects Caucasians, it is extremely uncommon among non-Caucasians.
Anogeianakis, George, Eminidou, Valeria, Loukovitis, Eleftherios, Pentara, Iro, Tsiropoulos , Georgios N., Tsotridou, Eleni, Tzima, Konstantina, Zapsalis, Konstantinos   +7 more
core   +2 more sources

Electrochemical lysis at the stage of endoresection for large posterior intraocular tumors

Oftalʹmologiâ, 2014
Purpose: to design the new combined technique of endoresection with intraoperative intraocular electrochemical lysis at the tumor destruction stage for large posterior intraocular tumors.Methods: 3 patients (3 eyes) with large choroidal melanomas t3N0M0 (
Yu. A. Belyy, A. V. Tereshchenko, A. V. Shatskih, D. K. Solovyov   +3 more
doaj   +3 more sources

Local treatment failure after globe-conserving therapy for choroidal melanoma. [PDF]

, 2013
Local treatment failure after globe-conserving therapy for choroidal melanoma is a surgical complication with significant morbidity to the vision and eye. Few reports in the literature have addressed this complication exclusively.
Chang, Melinda Y, McCannel, Tara A
core   +1 more source

Core Endoresection as Neoadjuvant Treatment of Uveal Melanoma [PDF]

Ocular Oncology and Pathology, 2015
<b><i>Aim:</i></b> To present a case of neoadjuvant treatment of uveal melanoma with a limited core endoresection, which enabled ruthenium plaque radiotherapy to be administered. <b><i>Material and Methods:</i></b> A 77-year-old woman presented in 2005 with a ciliochoroidal uveal melanoma measuring 7.2 by
Iwona Rospond-Kubiak, Carl Groenewald, Sarah E. Coupland, Bertil Damato   +3 more
openaire   +2 more sources