Results 1 to 10 of about 22,926 (249)

Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa

mBio, 2020
Posttranscriptional regulation plays an essential role in the quick adaptation of pathogenic bacteria to host environments, and RNases play key roles in this process by modifying small RNAs and mRNAs.
Yushan Xia, Yuding Weng, Congjuan Xu, Dan Wang, Xiaolei Pan, Zhenyang Tian, Bin Xia, Haozhou Li, Ronghao Chen, Chang Liu, Yongxin Jin, Fang Bai, Zhihui Cheng, Oscar P. Kuipers, Weihui Wu   +14 more
doaj   +2 more sources

Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15

Informatics in Medicine Unlocked, 2020
The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity.
D. Anantha Krishnan, G. Sangeetha, S. Vajravijayan, N. Nandhagopal, K. Gunasekaran   +4 more
doaj   +2 more sources

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cells [PDF]

Journal of Virology
Coronaviruses encode nonstructural protein 15 (Nsp15), a conserved endoribonuclease (EndoU) known to suppress host antiviral responses. It is imperative to understand the role of Nsp15/EndoU during severe acute respiratory syndrome coronavirus 2 (SARS ...
Xiang Chi, Xueying Liang, Kishore Vaddadi, Xiaoming Zhang, Chaitanya Gandikota, Sunil More, Lin Liu, Xufang Deng   +7 more
doaj   +2 more sources

Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut

Frontiers in Cellular and Infection Microbiology, 2022
The gut microbiome profile of COVID-19 patients was found to correlate with a viral load of SARS-CoV-2, COVID-19 severity, and dysfunctional immune responses, suggesting that gut microbiota may be involved in anti-infection.
Yao Ma, Mei Luo, Yusheng Deng, Xiaoman Yang, Xionglue Wang, Guozhong Chen, Zixin Qin, Yun Deng, Meiling Nan, Yang Chen, Peihui Wang, Hong Wei, Lijuan Han, Lijuan Han, Xiaodong Fang, Zhi Liu   +15 more
doaj   +2 more sources

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes [PDF]

Molecular Metabolism, 2019
Background: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed the unfolded ...
Rajarshi Ghosh, Kevin Colon-Negron, Feroz R. Papa   +2 more
doaj   +4 more sources

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage [PDF]

Nature Communications
The SLFN14 endoribonuclease is a post-transcriptional regulator that targets the ribosome and its associated RNA substrates for codon-bias translational repression. SLFN14 nuclease activity is linked to antiviral defense and platelet function.
Justin Van Riper, Arleth O. Martinez-Claros, Lie Wang, Hannah E. Schneiderman, Sweta Maheshwari, Monica C. Pillon   +5 more
doaj   +2 more sources

Natural Products from Red Algal Genus Laurencia as Potential Inhibitors of RdRp and nsp15 Enzymes of SARS-CoV-2: An In Silico Perspective

Microbiology Research, 2023
The genus Laurencia, a category of marine red algae, is well recognized for producing a large variety of natural products (NPs) that are both chemically intriguing and structurally distinct.
Omkar Pokharkar, Harshavardhan Anumolu, Grigory V. Zyryanov, Mikhail V. Tsurkan   +3 more
doaj   +1 more source

Detection and characterization of clustered regularly interspaced short palindromic repeat-associated endoribonuclease gene variants in Vibrio parahaemolyticus isolated from seafoods and environment [PDF]

Veterinary World, 2019
Aim: In Vibrio parahaemolyticus, the clustered regularly interspaced short palindromic repeat (CRISPR)-associated cas6 endoribonuclease gene has been shown to exhibit sequence diversity and has been subtyped into four major types based on its length and ...
Pallavi Baliga, Malathi Shekar, Moleyur Nagarajappa Venugopal   +2 more
doaj   +1 more source

Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo

Viruses, 2023
The emergence of SARS-CoV-1 in 2003 followed by MERS-CoV and now SARS-CoV-2 has proven the latent threat these viruses pose to humanity. While the SARS-CoV-2 pandemic has shifted to a stage of endemicity, the threat of new coronaviruses emerging from ...
Troy von Beck, Luis Mena Hernandez, Hongyi Zhou, Katharine Floyd, Mehul S. Suthar, Jeffrey Skolnick, Joshy Jacob   +6 more
doaj   +1 more source

ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response

Journal of Lipid Research, 2022
The unfolded protein response (UPR) is an elaborate signaling network that evolved to maintain proteostasis in the endoplasmic reticulum (ER) and mitochondria (mt).
Asli D. Yildirim, Mevlut Citir, Asli E. Dogan, Zehra Veli, Zehra Yildirim, Ozlem Tufanli, Alexis Traynor-Kaplan, Carsten Schultz, Ebru Erbay   +8 more
doaj   +1 more source