Results 91 to 100 of about 24,423 (298)
The endoribonuclease YbeY is linked to proper cellular morphology and virulence in 2 Brucella abortus [PDF]
, 2018 The endoribonuclease YbeY is one of the most well conserved proteins across the kingdoms of life. In the present study, we demonstrate that YbeY in Brucella abortus is linked to a variety of important activities, including proper cellular morphology ...
Budnick, James A. +5 more
core +1 more source
Journal of Virology, 2020 Coronaviruses can emerge from animal reservoirs into naive host species to cause pandemic respiratory and gastrointestinal diseases with significant mortality in humans and domestic animals.
J. Zhao +5 more
semanticscholar +1 more source
No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
Nature Communications, 2020 In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1
Albertas Navickas +5 more
doaj +1 more source
A conserved DYW domain of the pentatricopeptide repeat protein possesses a novel endoribonuclease activity [PDF]
, 2008 Many plant pentatricopeptide repeat (PPR) proteins are known to contain a highly conserved C-terminal DYW domain whose function is unknown. Recently, the DYW domain has been proposed to play a role in RNA editing in plant organelles.
Nakamura, Takahiro, Sugita, Mamoru
core +1 more source
Genome-wide analysis of thapsigargin-induced microRNAs and their targets in NIH3T3 cells
Genomics Data, 2014 Disruption of the endoplasmic reticulum (ER) homeostasis is the cause of ER stress. We performed microRNA (miRNA) analysis (deep sequencing) to search for coping responses (including signaling pathways) induced by disrupted ER Ca2+ homeostasis. Our focus
Jody Groenendyk +5 more
doaj +1 more source
Structure-based inhibitor screening of natural products against NSP15 of SARS- CoV-2 revealed Thymopentin and Oleuropein as potent inhibitors [PDF]
arXiv, 2020 Coronaviruses are enveloped, non-segmented positive-sense RNA viruses that have the largest genome among RNA viruses. The genome contains a large replicase ORF encodes nonstructural proteins (NSPs), structural and accessory genes. NSP15 is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) has C-terminal catalytic domain. The endoribonuclease
arxiv
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya +6 more
wiley +1 more source
Journal of Virology, 2018 The lethally pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus (SARS-CoV) pose serious threats to humans.
Lianqi Zhang +6 more
semanticscholar +1 more source