Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, Volume 8, Issue 6, June 2025.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Pyrimidine-specific cleavage by an endoribonuclease of Saccharomyces cerevisiae [PDF]
Journal of Bacteriology, 1985 An endoribonuclease with pyrimidine cleavage site specificity was isolated from Saccharomyces cerevisiae. The enzyme had a pH optimum of 6 to 7 and did not require a divalent cation. It was inhibited by 5 X 10(-5) M ethidium bromide, although it appeared to be single strand specific.
openaire +3 more sources
Bacillus subtilis RNase Y activity in vivo analysed by tiling microarrays. [PDF]
PLoS ONE, 2013 RNase Y is a key endoribonuclease affecting global mRNA stability in Bacillus subtilis. Its characterization provided the first evidence that endonucleolytic cleavage plays a major role in the mRNA metabolism of this organism.
Soumaya Laalami +5 more
doaj +1 more source
Characterization of the putative wobbly possum disease virus : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Virology at Massey University, Manawatū, New Zealand [PDF]
, 2017 The objective of this PhD was to characterise a marsupial arterivirus, termed wobbly possum disease virus (WPDV), and to confirm aetiological involvement of the virus in the development of a neurological disease of the Australian brushtail possum ...
Giles, Julia Christine
core
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 222-242, June 2025.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress [PDF]
The Ukrainian Biochemical Journal, 2014 Activation of pentose phosphate pathway is an important factor of enhanced cell proliferation and tumor growth. Phosphoribosyl pyrophosphate synthetase (PRPS) is a key enzyme of this pathway and plays a central role in the synthesis of purines and ...
O. H. Minchenko +4 more
doaj +1 more source
BMC Cell Biology, 2009 Background Parathyroid hormone (PTH) gene expression is regulated post-transcriptionally through the binding of the trans-acting proteins AU rich binding factor 1 (AUF1), Upstream of N-ras (Unr) and KH-type splicing regulatory protein (KSRP) to an AU ...
Schoenberg Daniel R +6 more
doaj +1 more source
A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni [PDF]
, 2015 The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood.
Arnoud H M Van Vliet +6 more
core +5 more sources
Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.ABSTRACT Xylella fastidiosa (Xf) is a Gram‐negative bacterial plant pathogen responsible for severe diseases in a variety of economically important crops. A critical aspect of its virulence is the production of extracellular vesicles (EVs). In this study, we discovered that DNA‐binding proteins and nonribosomal RNA‐binding proteins are abundant in the ...
Alessa Ruf +9 more
wiley +1 more source