Results 101 to 110 of about 24,718 (294)
Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases
CRISPR-associated endoribonucleases (Cas RNases) cleave single-stranded RNA in a highly sequence-specific manner by recognizing and binding to short RNA sequences known as direct repeats (DRs).
Sagar J. Parikh+8 more
doaj +1 more source
The lethally pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus (SARS-CoV) pose serious threats to humans.
Lianqi Zhang+6 more
semanticscholar +1 more source
Brucellosis is a debilitating disease of humans and animals globally, and there is currently no vaccine to combat human infection by Brucella spp. Moreover, effective antibiotic treatment in humans is extremely difficult and can lead to disease relapse ...
Lauren M Sheehan+5 more
semanticscholar +1 more source
The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner+5 more
wiley +1 more source
It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly
The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family.
M. Pillon+5 more
semanticscholar +1 more source
ESSENTIAL MEIOTIC ENDONUCLEASE 1 is required for chloroplast development and DNA repair in rice
Summary Chloroplast development is fundamental to photosynthesis and plant growth but is sensitive to environmental stress. Chloroplast development and division require genome stability and DNA repair, but the underlying mechanisms have been unclear. Using a forward genetic approach, we identified the striped‐leaf mutant k48 in the rice (Oryza sativa L.
Yanxin Du+5 more
wiley +1 more source
Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao+4 more
wiley +1 more source
Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth. [PDF]
Precision cancer therapy requires on the one hand detailed knowledge about a tumor's driver oncogenes and on the other hand an effective targeted therapy that specifically inhibits these oncogenes.
Nicole Bäumer+9 more
doaj +1 more source
RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease
The emerging disease SARS is caused by a novel coronavirus that encodes several unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine residues. How Nsp15 recognizes and cleaves RNA is not well understood and is the subject of this study.
Jingchuan Sun+4 more
openaire +3 more sources
Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter+7 more
core +5 more sources