Results 121 to 130 of about 24,423 (298)

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]

, 2015
Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista, A Onnis, AC Smith, AH Hutagalung, AL Kullas, AW van der Velden, BT Keady, C Cassioli, C Geisler, C Margadant, C T Baldari, C Wasmeier, CJ Westlake, CP Horgan, DA MacLeod, DS Gomez, E Schonteich, EM Manders, F Finetti, F Finetti, F Finetti, G Bonello, G Iezzi, G Patino-Lopez, GJ Pazour, H Soares, I Jordens, JA Follit, JC Stinchcombe, JK Chen, K Geddes, L Patrussi, L Patrussi, LB Pedersen, LI Ehrlich, M de la Roche, M Esquerré, M Gottardo, M Kurowska, MV Nachury, N Capitani, NB Martín-Cófreces, RS Kalupahana, S Pacini, S Spanò, S Spanò, S Spanò, S Wang, SR McGlashan, SY Wong, V Das, VM Wu   +51 more
core   +1 more source

Nimbolide Targeting SIRT1 Protects Against Acetaminophen‐Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Acetaminophen (APAP) is a major cause of acute liver injury (ALI), and N‐acetylcysteine is the only approved detoxification drug. Nimbolide (Nim), which is isolated from the neem tree (Azadirachta indica), possesses protective properties against multiple diseases, including pancreatitis, autoimmune hepatitis, arthritis, and diabetic ...
Junhui Ba, Yunsen Lin, Jingcong Zhang, Yanhong Wang, Benquan Wu   +4 more
wiley   +1 more source

Prediction of potential inhibitors against SARS-CoV-2 endoribonuclease: RNA immunity sensing

Journal of Biomolecular Structure and Dynamics, 2020
The World Health Organization has classified the COVID-19 outbreak a pandemic which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and declared it a global health emergency.
N. Al-Rashedi, Murad G Munahi, Laith Ah ALObaidi   +2 more
semanticscholar   +1 more source

Pyrimidine-specific cleavage by an endoribonuclease of Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1985
An endoribonuclease with pyrimidine cleavage site specificity was isolated from Saccharomyces cerevisiae. The enzyme had a pH optimum of 6 to 7 and did not require a divalent cation. It was inhibited by 5 X 10(-5) M ethidium bromide, although it appeared to be single strand specific.
openaire   +3 more sources

Circulating genomic biomarkers predict chemoradiotherapy resistance and immunotherapy response in locally advanced non‐small‐cell lung cancer

VIEW, Volume 6, Issue 3, June 2025.
The insufficient sensitivity of single circulating tumor DNA (ctDNA)‐molecular residual disease (MRD) prediction remains unresolved and hinders the clinical implementation of ctDNA. Through prospective cohort study, independent validations, and mechanism exploration from peripheral blood and tumor tissue, we demonstrate that ctDNA‐based STK11/KEAP1 ...
Yu Wang, Canjun Li, Tao Zhang, Jianyang Wang, Wenyang Liu, Lei Deng, Ying Jiang, Jinghao Duan, Luhua Wang, Hong Ge, Nan Bi   +10 more
wiley   +1 more source

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells

Biomolecules, 2020
While the role of hypoxia and the induction of the hypoxia inducible factors (HIFs) and the unfolded protein response (UPR) pathways in the cancer microenvironment are well characterized, their roles and relationship in normal human endothelium are less ...
Adrianna Moszyńska, J. Collawn, Rafał Bartoszewski   +2 more
semanticscholar   +1 more source

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells

BMC Cell Biology, 2009
Background Parathyroid hormone (PTH) gene expression is regulated post-transcriptionally through the binding of the trans-acting proteins AU rich binding factor 1 (AUF1), Upstream of N-ras (Unr) and KH-type splicing regulatory protein (KSRP) to an AU ...
Schoenberg Daniel R, Gherzi Roberto, Briata Paola, Bell Osnat, Peng Yong, Nechama Morris, Naveh-Many Tally   +6 more
doaj   +1 more source

An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. [PDF]

PLoS Biology, 2009
Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle (mRNP) assembly and surveillance.
Michal Skruzný, Claudia Schneider, Attila Rácz, Julan Weng, David Tollervey, Ed Hurt   +5 more
doaj   +1 more source

IRE1 alpha may be causing abnormal loss of p53 at post transcriptional level in chronic myeloid leukemia [PDF]

arXiv, 2017
Current treatment strategy for chronic myeloid leukemia (CML) mainly includes inhibition of tyrosine kinase activity, which has dramatically improved the prognosis of the disease but without cure. In addition some patients may become drug resistant. Thus there is still the need for other therapies to avoid resistance and if possible to cure the disease.
arxiv  

The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]

, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas, Drach, Kinoshita, Lim, Noguchi, Ohkura, Sazer, Suzuki   +7 more
core   +2 more sources