RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]
, 2019 Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue +5 more
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Journal of Biological Chemistry, 1983 Endoribonuclease VII, a novel endoribonuclease from calf thymus, was identified and purified by us. The purified enzyme has Mr = 74,000; its homogeneity was checked by analysis in polyacrylamide gels (both in the presence and in the absence of sodium dodecyl sulfate). The nuclease cleaves poly(U) and poly(C) while other single-stranded homopolyribo- as
Michael Bachmann +2 more
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Intramyocardial gene silencing by interfering RNA [PDF]
, 2017 RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases havea high incidence in
Brea, María Soledad +2 more
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Maturation of Polycistronic mRNAs by the Endoribonuclease RNase Y and Its Associated Y-Complex in Bacillus Subtilis [PDF]
, 2018 Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery, Aaron +3 more
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Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus [PDF]
, 2015 Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps)
Burgara Estrella, Alexel +3 more
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in vitro processing of HeLa cell preribosomes by a nucleolar endoribonuclease [PDF]
, 1972 Marc-Édouard Mirault, Klaus Scherrer
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Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity
Oncotarget, 2015 IRE1α is an endoplasmic reticulum (ER)-resident transmembrane signaling protein and a cellular stress sensor. The protein harbors a cytosolic dual kinase/endoribonuclease activity required for adaptive responses to micro-environmental changes. In an orthotopic xenograft model of human glioma, invalidation of IRE1α RNase or/and kinase activities ...
Jabouille, Arnaud +11 more
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Affinity Labelling and Characterization of the ppp(A2′p)nA‐Dependent Endoribonuclease from Different Mammalian Sources [PDF]
, 1982 Daniel H. Wreschner +4 more
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Informatics in Medicine Unlocked, 2020 The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity.
D. Anantha Krishnan +4 more
doaj
ERN1 KNOCKDOWN AFFECTS THE EXPRESSION OF PDHA1, PDHB, PDHX, DLD, AND DLAT GENES AND MODIFIES THEIR HYPOXIC REGULATION [PDF]
Biotechnologia ActaHypoxia and endoplasmic reticulum stress are critical factors affecting tumor growth. Inhibition of ERN1 protein has the ability to suppress glioma cell proliferation and growth. Pyruvate dehydrogenase complex is a important factor for glioma cell growth
Y.P. KHIKHLO +3 more
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