Results 141 to 150 of about 24,423 (298)
Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6
RNA: A publication of the RNA Society, 2016 Prokaryotic CRISPR–Cas systems provide an RNA-guided mechanism for genome defense against mobile genetic elements such as viruses and plasmids. In type III-A CRISPR–Cas systems, the RNA-guided multisubunit Csm effector complex targets both single ...
O. Niewoehner, M. Jinek
semanticscholar +1 more source
Mechanism of substrate selection by a highly specific CRISPR endoribonuclease [PDF]
RNA, 2012 Bacteria and archaea possess adaptive immune systems that rely on small RNAs for defense against invasive genetic elements. CRISPR (clustered regularly interspaced short palindromic repeats) genomic loci are transcribed as long precursor RNAs, which must be enzymatically cleaved to generate mature CRISPR-derived RNAs (crRNAs) that serve as guides for ...
Sternberg, Samuel H +2 more
openaire +5 more sources
Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death. [PDF]
, 2019 学位記番号 ...
Shibusawa, Ryo +2 more
core
Regulation and Function of the Atypical IκBs—Bcl‐3, IκBNS, and IκBζ—in Lymphocytes and Autoimmunity
European Journal of Immunology, Volume 55, Issue 5, May 2025.This review article summarizes the currently available information on the functions of atypical IκB proteins including Bcl‐3, IκBNS, and IκBζ, which have been studied mostly in mouse models. We focus on the regulation of these modulators of transcription, describe their role in lymphocyte differentiation, and their involvement in the development of ...
Tanja Kübelbeck +7 more
wiley +1 more source
Structure and Function of PRRSV nsp11 Endoribonuclease
DEStech Transactions on Biology and Health, 2018 Endoribonuclease (NendoU) is conserved and plays essential roles in viral life cycle among all nidoviruses. Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 11 (nsp11) is shown to have NendoU activity and its multifunctions have been demonstrated, such as processing RNA, suppressing innate immunity system of infected ...
Zhong-Zhou Chen, Wei Wu, Manfeng Zhang
openaire +3 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Harnessing promoter elements to enhance gene editing in plants: perspectives and advances
Plant Biotechnology Journal, Volume 23, Issue 5, Page 1375-1395, May 2025.Summary Genome‐edited plants, endowed with climate‐smart traits, have been promoted as tools for strengthening resilience against climate change. Successful plant gene editing (GE) requires precise regulation of the GE machinery, a process controlled by the promoters, which drives its transcription through interactions with transcription factors (TFs ...
Nikita Gondalia +8 more
wiley +1 more source
Horticulture Research, 2019 The formation of flowers in higher plants is controlled by complex gene regulatory networks. The study of floral development in Arabidopsis is promoted and maintained by transposon-tagged mutant lines.
Yingzhu Liu +3 more
semanticscholar +1 more source
Structural Principles of CRISPR RNA Processing [PDF]
, 2015 The Cas6 superfamily, the Cas5d subclass, and the host RNase III endoribonucleases are responsible for producing small RNAs (crRNA) that function in the CRISPR-Cas immunity.
Li, Hong
core +1 more source
Microbial Biotechnology, Volume 18, Issue 4, April 2025.All 32 diguanylate cyclase (DGC)‐encoding genes of P. aeruginosa PA14 were interrupted by premature STOP codons, introduced through a multiplexed cytosine base‐editor. The synthesis of c‐di‐GMP was impaired in the resulting strain lacking all 32 DGCs (strain PA14Δ32). Phenotypic analysis confirmed major behaviour changes in P. aeruginosa PA14Δ32, which
Román A. Martino +5 more
wiley +1 more source