Cancer Science, 2019 Cholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelium and its incidence is increasing year by year. In recent years, long noncoding RNAs (lncRNAs) have been found to play an important role in the occurrence and progression ...
Lingyu Tang +8 more
semanticscholar +1 more source
Future Drug Discovery, 2020 COVID-19 has become the gravest global public health crisis since the Spanish Flu of 1918. Combination antiviral therapy with repurposed broad-spectrum antiviral agents holds a highly promising immediate treatment strategy, especially given uncertainties
Suranga L Senanayake
semanticscholar +1 more source
A novel mechanism of RNase L inhibition: Theiler\u27s virus L* protein prevents 2-5A from binding to RNase L [PDF]
, 2018 The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread ...
Drappier, Melissa +8 more
core +4 more sources
IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor
Allergy, Volume 80, Issue 4, Page 965-975, April 2025.Human B cells express IL‐17RB under IgE inducing conditions (anti‐CD40 + IL‐4) and respond to IL‐25 with enhanced antibody production, particularly IgE. ScRNA‐seq revealed that IL‐17RB+ B cells have a distinct transcriptional profile compared to IL‐17RB‐B cells.
Semah Abdu +10 more
wiley +1 more source
Novel Mutation in Boy With Cartilage-hair Hypoplasia [PDF]
, 2010 BackgroundCartilage-hair hypoplasia (MIM 250250) is an autosomal recessive disease with diverse clinical manifestations. The clinical phenotypes include variable degrees of bone and hair dysplasia, deficient cellular and/or humoral immunity, and a ...
Lin, I-Chun +3 more
core +2 more sources
Composition and conservation of the mRNA-degrading machinery in bacteria [PDF]
, 2011 RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts.
Dharam Singh +2 more
core +4 more sources
An improved CRISPRi system in Pichia pastoris
Synthetic and Systems Biotechnology, 2023 CRISPR interference (CRISPRi) has been developed and widely used for gene repression in various hosts. Here we report an improved CRISPRi system in Pichia pastoris by fusing dCas9 with endogenous transcriptional repressor domains.
Shujing Qiao +4 more
doaj
The first small-molecule inhibitors of members of the ribonuclease E family [PDF]
, 2015 The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression.
A Danchin +43 more
core +4 more sources
Characterization of the putative wobbly possum disease virus : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Virology at Massey University, Manawatū, New Zealand [PDF]
, 2017 The objective of this PhD was to characterise a marsupial arterivirus, termed wobbly possum disease virus (WPDV), and to confirm aetiological involvement of the virus in the development of a neurological disease of the Australian brushtail possum ...
Giles, Julia Christine
core
Impact of alternative carbon sources and antifungal treatment on Candida glabrata biofilms transcription profile [PDF]
, 2016 Candida glabrata is considered a major opportunistic fungal pathogen of humans and has emerged as a leading cause of nosocomial fungal infections. The capacity of this yeast species to cause infections is dependent on the ability to grow within the human
Alves, Rosana +8 more
core +1 more source