Journal of Biological Chemistry, 1983 Endoribonuclease VII, a novel endoribonuclease from calf thymus, was identified and purified by us. The purified enzyme has Mr = 74,000; its homogeneity was checked by analysis in polyacrylamide gels (both in the presence and in the absence of sodium dodecyl sulfate). The nuclease cleaves poly(U) and poly(C) while other single-stranded homopolyribo- as
Michael Bachmann +2 more
openaire +3 more sources
YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity [PDF]
, 2017 As a typical endoribonuclease, YoeB mediates cellular adaptation in diverse bacteria by degrading mRNAs on its activation. Although the catalytic core of YoeB is thought to be identical to well-studied nucleases, this enzyme specifically targets mRNA ...
Chen, Yun +6 more
core
Broadening the phenotypic spectrum of POP1-skeletal dysplasias: identification of POP1 mutations in a mild and severe skeletal dysplasia. [PDF]
, 2017 POP1 is a large protein common to the RNase-MRP and RNase-P (RMRP) endoribonucleoprotein complexes. Although its precise function is unknown, it appears to participate in the assembly or stability of both complexes.
Bonafé +40 more
core +3 more sources
Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia [PDF]
, 2011 Producción CientíficaBackground: Cartilage-hair hypoplasia (CHH) is characterized by metaphyseal dysplasia, bone marrow failure, increased risk of malignancies, and a variable degree of immunodeficiency. CHH is caused by mutations in the RNA component of
Adair, Margaret +14 more
core +1 more source
in vitro processing of HeLa cell preribosomes by a nucleolar endoribonuclease [PDF]
, 1972 Marc-Édouard Mirault, Klaus Scherrer
openalex +1 more source
Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease
RNA Biology, 2019 Prokaryotic CRISPR-Cas adaptive immune systems rely on small non-coding RNAs derived from CRISPR loci to recognize and destroy complementary nucleic acids. However, the mechanism of Type IV CRISPR RNA (crRNA) biogenesis is poorly understood.
Hannah N. Taylor +5 more
semanticscholar +1 more source
Journal of Virology, 2018 In response to virus-induced shutoff host protein synthesis, dynamic aggregates containing mRNA, RNA-binding proteins and translation factors termed stress granules (SGs) often accumulate within the cytoplasm. SGs typically form following phosphorylation
Hannah M Burgess, I. Mohr
semanticscholar +1 more source
Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity
Oncotarget, 2015 IRE1α is an endoplasmic reticulum (ER)-resident transmembrane signaling protein and a cellular stress sensor. The protein harbors a cytosolic dual kinase/endoribonuclease activity required for adaptive responses to micro-environmental changes. In an orthotopic xenograft model of human glioma, invalidation of IRE1α RNase or/and kinase activities ...
Jabouille, Arnaud +11 more
openaire +5 more sources
ERN1 KNOCKDOWN AFFECTS THE EXPRESSION OF PDHA1, PDHB, PDHX, DLD, AND DLAT GENES AND MODIFIES THEIR HYPOXIC REGULATION [PDF]
Biotechnologia ActaHypoxia and endoplasmic reticulum stress are critical factors affecting tumor growth. Inhibition of ERN1 protein has the ability to suppress glioma cell proliferation and growth. Pyruvate dehydrogenase complex is a important factor for glioma cell growth
Y.P. KHIKHLO +3 more
doaj +1 more source
Affinity Labelling and Characterization of the ppp(A2′p)nA‐Dependent Endoribonuclease from Different Mammalian Sources [PDF]
, 1982 Daniel H. Wreschner +4 more
openalex +1 more source