Results 11 to 20 of about 24,423 (298)

Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity [PDF]

Molecular Biology, 2021
Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg2+-dependent hydrolysis of AP-sites in DNA.
A. Kuznetsova, A. A. Gavrilova, D. Novopashina, O. Fedorova, N. Kuznetsov   +4 more
semanticscholar   +5 more sources

Substrate specificity of human MCPIP1 endoribonuclease [PDF]

Scientific Reports, 2018
MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded
Mateusz Wilamowski, Andrzej Gorecki, Marta Dziedzicka-Wasylewska, Jolanta Jura   +3 more
doaj   +4 more sources

Innate Immune Evasion of PRRSV nsp11 through Degradation of the HDAC2 by Its Endoribonuclease Activity [PDF]

Viruses
Porcine reproductive and respiratory syndrome virus (PRRSV), a member of the Arteriviridae family, represents a persistent menace to the global pig industry, causing reproductive failure and respiratory disease in pigs.
He Zhang, Jianxing Chen, Changqing Yu, Yu Pan, Wenjie Ma, Hao Feng, Jinxin Xie, Hongyan Chen, Yue Wang, Changyou Xia   +9 more
doaj   +2 more sources

Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa

mBio, 2020
Posttranscriptional regulation plays an essential role in the quick adaptation of pathogenic bacteria to host environments, and RNases play key roles in this process by modifying small RNAs and mRNAs.
Yushan Xia, Yuding Weng, Congjuan Xu, Dan Wang, Xiaolei Pan, Zhenyang Tian, Bin Xia, Haozhou Li, Ronghao Chen, Chang Liu, Yongxin Jin, Fang Bai, Zhihui Cheng, Oscar P. Kuipers, Weihui Wu   +14 more
doaj   +2 more sources

Substrate specificity of bacterial endoribonuclease toxins

BMB Reports, 2020
Bacterial endoribonuclease toxins belong to a protein family that inhibits bacterial growth by degrading mRNA or rRNA sequences. The toxin genes are organized in pairs with its cognate antitoxins in the chromosome and thus the activities of the toxins ...
Yoontak Han, Eun-Jin Lee
semanticscholar   +5 more sources

Phylogenetic analysis of the endoribonuclease Dicer family. [PDF]

PLoS ONE, 2014
Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level.
Zeqian Gao, Miao Wang, David Blair, Yadong Zheng, Yongxi Dou   +4 more
doaj   +6 more sources

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

Journal of Medicinal Chemistry, 2019
A series of imidazo[1,2-b]pyridazin-8-amine kinase inhibitors were discovered to allosterically inhibit the endoribonuclease function of the dual kinase-endoribonuclease inositol-requiring enzyme 1α (IRE1α), a key component of the unfolded protein ...
Thomas P Matthews, N Yi Mok, Alan M Jones   +2 more
exaly   +2 more sources

Preferential cleavage of the coronavirus defective viral genome by cellular endoribonuclease with characteristics of RNase L [PDF]

Virology Journal
In testing whether coronavirus defective viral genome 12.7 (DVG12.7) with transcription regulating sequence (TRS) can synthesize subgenomic mRNA (sgmRNA) in coronavirus-infected cells, it was unexpectedly found by Northern blot assay that not only sgmRNA
Ching-Hung Lin, Hsuan-Yung Lin, Chun-Chun Yang, Hsuan-Wei Hsu, Feng-Cheng Hsieh, Cheng-Yao Yang, Hung-Yi Wu   +6 more
doaj   +2 more sources

Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom [PDF]

, 2015
SummaryPIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated ...
Dohmae, Naoshi, Ishitani, Ryuichiro, Matsumoto, Naoki, Miyakubi, Kana, Namba, Yurika, Nishimasu, Hiroshi, Nureki, Osamu, Sato, Kaoru, Siomi, Haruhiko, Siomi, Mikiko C.   +9 more
core   +4 more sources

Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15

Informatics in Medicine Unlocked, 2020
The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to humanity.
D. Anantha Krishnan, G. Sangeetha, S. Vajravijayan, N. Nandhagopal, K. Gunasekaran   +4 more
doaj   +2 more sources