Results 11 to 20 of about 22,136 (261)
Substrate specificity of human MCPIP1 endoribonuclease [PDF]
Scientific Reports, 2018 MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an endonuclease by degrading several stem-loop RNA structures and single-stranded
Mateusz Wilamowski +3 more
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Phylogenetic analysis of the endoribonuclease Dicer family. [PDF]
PLoS ONE, 2014 Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level.
Zeqian Gao +4 more
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Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes [PDF]
Molecular Metabolism, 2019 Background: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed the unfolded ...
Rajarshi Ghosh +2 more
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Structural Biology of the Arterivirus nsp11 Endoribonucleases [PDF]
Journal of Virology, 2016 ABSTRACT Endoribonuclease (NendoU) is unique and conserved as a major genetic marker in nidoviruses that infect vertebrate hosts. Arterivirus nonstructural protein 11 (nsp11) was shown to have NendoU activity and play essential roles in the viral life cycle.
Manfeng Zhang +7 more
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Microbiology Research, 2023 The genus Laurencia, a category of marine red algae, is well recognized for producing a large variety of natural products (NPs) that are both chemically intriguing and structurally distinct.
Omkar Pokharkar +3 more
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Detection and characterization of clustered regularly interspaced short palindromic repeat-associated endoribonuclease gene variants in Vibrio parahaemolyticus isolated from seafoods and environment [PDF]
Veterinary World, 2019 Aim: In Vibrio parahaemolyticus, the clustered regularly interspaced short palindromic repeat (CRISPR)-associated cas6 endoribonuclease gene has been shown to exhibit sequence diversity and has been subtyped into four major types based on its length and ...
Pallavi Baliga +2 more
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Viruses, 2023 The emergence of SARS-CoV-1 in 2003 followed by MERS-CoV and now SARS-CoV-2 has proven the latent threat these viruses pose to humanity. While the SARS-CoV-2 pandemic has shifted to a stage of endemicity, the threat of new coronaviruses emerging from ...
Troy von Beck +6 more
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A Novel Endoribonuclease, RNase LS, in Escherichia coli [PDF]
Genetics, 2005 Abstract The dmd gene of bacteriophage T4 is required for the stability of late-gene mRNAs. When this gene is mutated, late genes are globally silenced because of rapid degradation of their mRNAs. Our previous work suggested that a novel Escherichia coli endonuclease, RNase LS, is responsible for the rapid degradation of mRNAs.
Yuichi Otsuka, Tetsuro Yonesaki
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Sequence-specific endoribonucleases
Postępy Biochemii, 2016 Ribonucleases are nucleolytic enzymes that commonly occur in living organisms and act by cleaving RNA molecules. These enzymes are involved in basic cellular processes, including the RNA maturation that accompanies the formation of functional RNAs, as well as RNA degradation that enables removal of defective or dangerous molecules or ones that have ...
Dawid Głów +3 more
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Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity [PDF]
Molecular Biology, 2021 Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg^(2+)-dependent hydrolysis of AP-sites in DNA. On the base of structural data, kinetic studies, and mutation analysis, the key stages of APE1 interaction with damaged DNA were established.
Alexandra A. Kuznetsova +5 more
openaire +3 more sources