Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes [PDF]
Molecular Metabolism, 2019 Background: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed the unfolded ...
Rajarshi Ghosh +2 more
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What is the link between stringent response, endoribonuclease encoding Type II Toxin-Antitoxin systems and persistence? [PDF]
Frontiers in Microbiology, 2016 Persistence is a transient and non-inheritable tolerance to antibiotics by a small fraction of a bacterial population. One of the proposed determinants of bacterial persistence is toxin-antitoxin systems (TAS) which are also implicated in a wide range of
Bhaskar Chandra Mohan Ramisetty +4 more
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Structural Biology of the Arterivirus nsp11 Endoribonucleases [PDF]
Journal of Virology, 2016 ABSTRACT Endoribonuclease (NendoU) is unique and conserved as a major genetic marker in nidoviruses that infect vertebrate hosts. Arterivirus nonstructural protein 11 (nsp11) was shown to have NendoU activity and play essential roles in the viral life cycle.
Manfeng Zhang +7 more
openalex +4 more sources
A Novel Endoribonuclease, RNase LS, in Escherichia coli [PDF]
Genetics, 2005 Abstract The dmd gene of bacteriophage T4 is required for the stability of late-gene mRNAs. When this gene is mutated, late genes are globally silenced because of rapid degradation of their mRNAs. Our previous work suggested that a novel Escherichia coli endonuclease, RNase LS, is responsible for the rapid degradation of mRNAs.
Yuichi Otsuka, Tetsuro Yonesaki
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The RasGAP-associated endoribonuclease G3BP mediates stress granule assembly
Journal of Cell Biology, 2023 In this Report, which replaces the previous retracted version, the authors show that G3BP is an effector of SG assembly, and that Ras signaling contributes to this process by regulating G3BP dephosphorylation.
H. Tourrière +6 more
semanticscholar +1 more source
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling
bioRxiv, 2023 Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of deaths since emerging in 2019. Innate immune antagonism by lethal CoVs such as SARS-CoV-2 is crucial for optimal replication and pathogenesis.
Clayton J. Otter +12 more
semanticscholar +1 more source
The Plant Cell, 2023 In plants, cytoplasmic mRNA decay is critical for posttranscriptionally controlling gene expression and for maintaining cellular RNA homeostasis. Arabidopsis DCP1-ASSOCIATED NYN ENDORIBONUCLEASE 1 (DNE1) is a cytoplasmic mRNA decay factor that interacts ...
V. Nagarajan +5 more
semanticscholar +1 more source
Microbiology Research, 2023 The genus Laurencia, a category of marine red algae, is well recognized for producing a large variety of natural products (NPs) that are both chemically intriguing and structurally distinct.
Omkar Pokharkar +3 more
doaj +1 more source
Detection and characterization of clustered regularly interspaced short palindromic repeat-associated endoribonuclease gene variants in Vibrio parahaemolyticus isolated from seafoods and environment [PDF]
Veterinary World, 2019 Aim: In Vibrio parahaemolyticus, the clustered regularly interspaced short palindromic repeat (CRISPR)-associated cas6 endoribonuclease gene has been shown to exhibit sequence diversity and has been subtyped into four major types based on its length and ...
Pallavi Baliga +2 more
doaj +1 more source