Results 31 to 40 of about 24,423 (298)
Viruses, 2023 The emergence of SARS-CoV-1 in 2003 followed by MERS-CoV and now SARS-CoV-2 has proven the latent threat these viruses pose to humanity. While the SARS-CoV-2 pandemic has shifted to a stage of endemicity, the threat of new coronaviruses emerging from ...
Troy von Beck +6 more
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Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
bioRxiv, 2022 Coronaviruses generate double-stranded (ds) RNA intermediates during viral replication that can activate host immune sensors. To evade activation of the host pattern recognition receptor MDA5, coronaviruses employ Nsp15, which is uridine-specific ...
M. Frazier +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Middle East respiratory syndrome coronavirus (MERS-CoV) causes highly lethal respiratory disease. MERS-CoV encodes innate immune antagonists, including accessory proteins NS4a and NS4b, unique to the merbeco lineage of betacoronaviruses, and
Courtney E. Comar +9 more
semanticscholar +1 more source
JCI Insight, 2022 Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology.
S. Marek-Iannucci +11 more
semanticscholar +1 more source
Sequence-specific endoribonucleases
Postępy Biochemii, 2016 Ribonucleases are nucleolytic enzymes that commonly occur in living organisms and act by cleaving RNA molecules. These enzymes are involved in basic cellular processes, including the RNA maturation that accompanies the formation of functional RNAs, as well as RNA degradation that enables removal of defective or dangerous molecules or ones that have ...
Dawid Głów +3 more
openalex +4 more sources
Frontiers in Microbiology, 2022 Ribosome assembly is a complex fundamental cellular process that involves assembling multiple ribosomal proteins and several ribosomal RNA species in a highly coordinated yet flexible and resilient manner.
Vignesh M. P. Babu +3 more
doaj +1 more source
Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
bioRxiv, 2022 SARS-CoV-2 is the causative agent of COVID-19. The highly conserved viral NSP15 endoribonuclease, NendoU, is a key enzyme involved in viral immune evasion, and a promising target for the development of new classes of antivirals. Yet, the broad variety of
A. Godoy +23 more
semanticscholar +1 more source
Colicin E3: A Unique Endoribonuclease [PDF]
Proceedings of the National Academy of Sciences, 1973 The question of whether or not a cellular ribonuclease is involved in the cleavage of 16S ribosomal RNA by colicin E3 was investigated. For this purpose ribosomes from strains devoid of some ribonucleases or ribosomes in which ribonucleases had been inactivated by heat or removed by extensive washings were used for the colicin reaction.
Irene Meyhack +2 more
openaire +3 more sources
Microbiology Spectrum, 2023 Endoribonuclease non-structural protein 15 (nsp15) (EndoU) is conserved among coronaviruses (CoVs) and is crucial for viral replication, evasion of the innate immune system, and virulence.
Yunfei Xie +10 more
doaj +1 more source
Journal of Virology, 2022 Endoribonuclease is conserved in coronaviruses and affects viral replication and pathogenicity. Infectious bronchitis virus (IBV), a γ-coronavirus, infects respiratory, renal, and reproductive systems, causing millions of dollars in lost revenue to the ...
Jing Zhao +5 more
semanticscholar +1 more source