The endoribonucleolytic N-terminal half of Escherichia coli RNase E is evolutionarily conserved in Synechocystis sp. and other bacteria but not the C-terminal half, which is sufficient for degradosome assembly [PDF]
, 1998 Escherichia coli RNase E, an essential single-stranded specific endoribonuclease, is required for both ribosomal RNA processing and the rapid degradation of mRNA.
Jakobsen, J.S. +5 more
core +2 more sources
Interplay between endoplasmic reticulum (ER) stress and autophagy induces mutant p53H273 degradation [PDF]
, 2020 The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress.
Cirone, Mara +5 more
core +1 more source
An assay of ribonuclease H, endoribonucleases, and phosphatases. [PDF]
Proceedings of the National Academy of Sciences, 1976 An assay for ribonuclease H (EC 3.1.4.34) is described which permits the estimation of the number and the type of cleavages produced by the enzyme when acting on the ribo moiety of a DNA-RNA hybrid substrate. With six different homopolymer hybrids tested, the number of enzymically induced breaks varied widely.
J G Starvianopoulos, E Chargaff
openaire +3 more sources
Journal of Lipid Research, 2022 The unfolded protein response (UPR) is an elaborate signaling network that evolved to maintain proteostasis in the endoplasmic reticulum (ER) and mitochondria (mt).
Asli D. Yildirim +8 more
doaj
Toxin-Antitoxin Systems as Multilevel Interaction Systems
Toxins, 2014 Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
doaj +1 more source
Mouse tafazzin is required for male germ cell meiosis and spermatogenesis [PDF]
, 2015 Barth syndrome is an X-linked mitochondrial disease, symptoms of which include neutropenia and cardiac myopathy. These symptoms are the most significant clinical consequences of a disease, which is increasingly recognised to have a variable presentation.
Bryson, S. +6 more
core +12 more sources
Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease
eLife, 2018 Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail.
Ilaria Pettinati +7 more
doaj +1 more source
Journal of Biomolecular Structure and Dynamics, 2020 SARS-CoV-2 is causative agent of COVID-19, which is responsible for severe social and economic disruption globally. Lack of vaccine or antiviral drug with clinical efficacy suggested that drug repurposing approach may provide a quick therapeutic solution
Anshuman Chandra +3 more
semanticscholar +1 more source
The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids [PDF]
, 2014 Hemocytes of Heliothis virescens (F.) (Lepidoptera, Noctuidae) larvae produce a protein, P102, with a putative endoribonuclease-U domain. In previous works we have shown that P102 is involved in Lepidopteran immune response by forming amyloid fibrils ...
Falabella, P. +7 more
core +1 more source
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease
Journal of Biological Chemistry, 2023 The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate this disease have focused on the development of vaccines and on drugs that inhibit the viral 3CL protease or RNA-dependent RNA polymerase ...
Jerry Chen +14 more
openaire +2 more sources