Results 71 to 80 of about 22,926 (249)

Turkey Coronavirus Non-Structure Protein NSP15 – An Endoribonuclease [PDF]

Intervirology, 2008
Turkey coronavirus (TCoV) polyprotein was predicted to be cleaved into 15 non-structural proteins (nsp2 to nsp16), but none of these nsps have been characterized. TCoV nsp15 consists of 338 residues and shares 40% sequence similarity to U-specific <i>Nidovirales</i> endoribonuclease (NendoU) of severe acute respiratory syndrome coronavirus.
Jianzhong, Cao, Ching-Ching, Wu, Tsang Long, Lin   +2 more
openaire   +2 more sources

Unusual Cytology Features of A DICER1‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Cytopathology, EarlyView.
This article describes the unusual cytology features of a DICER1‐mutated thyroid nodule. Fine needle aspiration revealed predominantly cell debris/degenerated cells and rare viable follicular cells with mild cytologic atypia. Surgical resection revealed a nodule with nearly complete infarction, which is one specific feature of DICER1‐mutated thyroid ...
Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, Qian Wang   +3 more
wiley   +1 more source

The FsrA‐Mediated Iron‐Sparing Response Regulates the Biosynthesis of the Epipeptide EPE in Bacillus subtilis

Molecular Microbiology, EarlyView.
Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke, Rabea Ghandour, Kai Papenfort, Thorsten Mascher   +3 more
wiley   +1 more source

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication.

PLoS Pathogens, 2021
Cytoplasmic stress granules (SGs) are generally triggered by stress-induced translation arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due to their involvement in protein synthesis shut off and recruitment of ...
Bo Gao, Xiaoqian Gong, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao   +14 more
doaj   +1 more source

Functional Mapping of AGO-Associated Zika Virus-Derived Small Interfering RNAs in Neural Stem Cells

Frontiers in Cellular and Infection Microbiology, 2021
Viral interfering RNA (viRNA) has been identified from several viral genomes via directly deep RNA sequencing of the virus-infected cells, including zika virus (ZIKV).
Jianxiong Zeng, Jianxiong Zeng, Zhifei Luo, Shupeng Dong, Shupeng Dong, Xiaochun Xie, Xiaochun Xie, Xinyan Liang, Xinyan Liang, Youzhen Yan, Youzhen Yan, Qiming Liang, Qiming Liang, Zhen Zhao, Zhen Zhao   +14 more
doaj   +1 more source

The first small-molecule inhibitors of members of the ribonuclease E family [PDF]

, 2015
The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression.
A Danchin, A Koul, AJ Callaghan, AJ Callaghan, AJ Callaghan, AJ Carpousis, AJ Carpousis, AP Walsh, AR Subramanian, BK Ghora, BK Mohanty, BK Shoichet, C Condon, C Condon, C Dye, CM Arraiano, D Apirion, D Suck, GA Mackie, JE Clarke, K Lee, KH Bleicher, KJ McDowall, KJ McDowall, L Kime, L Kime, M Kuwano, M Ono, M Wachi, MC Ow, MHJ Seifert, MJ Marcaida, N Guex, O Guner, O Zelenko, SM Garrey, SS Jourdan, V Khemici, VJ Gillet, VR Kaberdin, XQ Jiang, Y Redko, Z Zsoldos, ZW Li   +43 more
core   +4 more sources

Interplay between endoplasmic reticulum (ER) stress and autophagy induces mutant p53H273 degradation [PDF]

, 2020
The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress.
Cirone, Mara, Crispini, Alessandra, D'Orazi, Gabriella, Federici, Giulia, Garufi, Alessia, Gilardini Montani, Maria Saveria   +5 more
core   +1 more source

Endoribonucleases associated with RNAs in chick embryos

FEBS Letters, 1979
proteins in hemopoietic rat cells were reported to have RNase activities [ 121. Similarly, an endogeneous endoribonucleolytic activity was found in the 50 S ribosomal subunit of Eschenihia coli [ 131. This paper describes the existence of a RNA-bound cytoplasmic endoribonuclease in chick embryo.
Denoya, Claudio D., Scodeller, Eduardo A., La torre, José L.   +2 more
openaire   +2 more sources

Bacillus subtilis RNase HII Is Inefficient at Processing Guanosine Monophosphate and Damaged Ribonucleotides

Molecular Microbiology, EarlyView.
Bacillus subtilis RNase HII corrects ribonucleotide errors and mismatched ribonucleotides, but not damaged ribonucleotides. Mismatched ribonucleotides would also serve as substrates for mismatch repair while damaged ribonucleotides would be addressed through base excision repair.
Julianna R. Cresti, Lyle A. Simmons
wiley   +1 more source

Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth. [PDF]

PLoS ONE, 2018
Precision cancer therapy requires on the one hand detailed knowledge about a tumor's driver oncogenes and on the other hand an effective targeted therapy that specifically inhibits these oncogenes.
Nicole Bäumer, Jan Rehkämper, Neele Appel, Lisa Terheyden, Wolfgang Hartmann, Eva Wardelmann, Frank Buchholz, Carsten Müller-Tidow, Wolfgang E Berdel, Sebastian Bäumer   +9 more
doaj   +1 more source