Results 81 to 90 of about 24,423 (298)

Altered endoribonuclease activity of apurinic/apyrimidinic endonuclease 1 variants identified in the human population.

PLoS ONE, 2014
Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in the DNA base excision repair pathway and cleaves the DNA phosphodiester backbone immediately 5' to abasic sites. APE1 also has 3'-5' DNA exonuclease and 3' DNA phosphodiesterase
Wan Cheol Kim, Conan Ma, Wai-Ming Li, Manbir Chohan, David M Wilson, Chow H Lee   +5 more
doaj   +1 more source

Gene autoregulation by 3’ UTR-derived bacterial small RNAs

eLife, 2020
Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a ...
Mona Hoyos, Michaela Huber, Konrad U Förstner, Kai Papenfort   +3 more
doaj   +1 more source

The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

Scientific Reports, 2021
Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR).
Quynh Giang Le, Yuki Ishiwata-Kimata, Thi Huong Phuong, Shigeto Fukunaka, Kenji Kohno, Yukio Kimata   +5 more
doaj   +1 more source

Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut

Frontiers in Cellular and Infection Microbiology, 2022
The gut microbiome profile of COVID-19 patients was found to correlate with a viral load of SARS-CoV-2, COVID-19 severity, and dysfunctional immune responses, suggesting that gut microbiota may be involved in anti-infection.
Yao Ma, Mei Luo, Yusheng Deng, Xiaoman Yang, Xionglue Wang, Guozhong Chen, Zixin Qin, Yun Deng, Meiling Nan, Yang Chen, Peihui Wang, Hong Wei, Lijuan Han, Lijuan Han, Xiaodong Fang, Zhi Liu   +15 more
doaj   +1 more source

In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2

Journal of Biomolecular Structure and Dynamics, 2020
Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode.
Anil K Sharma, S. Goyal, A. Yadav, Pawan Kumar, Lovely Gupta   +4 more
semanticscholar   +1 more source

Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses

Journal of Virology, 2019
Coronaviruses (CoVs) can emerge from an animal reservoir into a naive host species to cause pandemic respiratory or gastrointestinal diseases with significant mortality in humans or domestic animals.
Xufang Deng, A. V. van Geelen, A. Buckley, A. O’Brien, Angela Pillatzki, K. Lager, K. Faaberg, S. Baker   +7 more
semanticscholar   +1 more source

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages

Journal of Virology, 2020
Macrophages are an important cell type during coronavirus infections because they “notice” the infection and respond by inducing type I interferons, which limits virus replication.
Aaron Volk, M. Hackbart, Xufang Deng, Yazmin E Cruz-Pulido, A. O’Brien, S. Baker   +5 more
semanticscholar   +1 more source

The Tumor Marker Human Placental Protein 11 Is an Endoribonuclease [PDF]

Journal of Biological Chemistry, 2008
Human PP11 (placental protein 11) was previously described as a serine protease specifically expressed in the syncytiotrophoblast and in numerous tumor tissues. Several PP11-like proteins were annotated in distantly related organisms, such as worms and mammals, suggesting their involvement in evolutionarily conserved processes.
Pietro Laneve, GIOIA, UBALDO, RAGNO, Rino, ALTIERI, Fabio, DI FRANCO, Carmela Antonia, SANTINI, Tiziana, M. Arceci, BOZZONI, Irene, E. Caffarelli   +8 more
openaire   +6 more sources

The HIV-1 Protein Vpr Targets the Endoribonuclease Dicer for Proteasomal Degradation to Boost Macrophage Infection [PDF]

, 2013
The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4DCAF1 ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands.
de Noronha, Carlos M.C., Flagg, Meg, Furuya, Andrea K.M., Klockow, Laurieann, Nekorchuk, Michael, Sharifi, Hamayun J., Wen, Xiaoyun   +6 more
core   +2 more sources

In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of SARS CoV-2

Journal of Biomolecular Structure and Dynamics, 2020
Coronavirus Disease (COVID-19) is recently declared pandemic (WHO) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The virus was named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), (Coronavirus Disease 2019 ...
A. Maurya, N. Mishra
semanticscholar   +1 more source