Results 241 to 250 of about 9,566 (262)
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Structural basis for human mitochondrial tRNA maturation
bioRxiv, 2023The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain.
Vincent Meynier +9 more
semanticscholar +1 more source
Influenza Virus Endoribonuclease
2001The influenza virus polymerase complex contains two associated enzymatic activities, an endoribonuclease and a RNA-dependent RNA polymerase activity. Both activities have so far been observed only with the complete polymerase complex consisting of three subunits, PB1, PB2, and PA.
Lisa Hooker +2 more
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Chloroplast p54 Endoribonuclease
2001Publisher Summary Much of the regulation of chloroplast gene expression has been assigned to stability determinants at the level of RNA precursors, including interactions of sequence and/or structural elements with their cognate binding proteins. A number of these proteins are known to assemble at the 5′-untranslated region (UTR) of chloroplast mRNAs,
Karsten Liere +2 more
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Purification and characterization of a novel mammalian endoribonuclease
Journal of Cellular Biochemistry, 2005AbstractEndonuclease‐mediated mRNA decay appears to be a common mode of mRNA degradation in mammalian cells, but yet only a few mRNA endonucleases have been described. Here, we report the existence of a second mammalian endonuclease that is capable of cleaving c‐myc mRNA within the coding region in vitro.
Joel C. Urquhart +4 more
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A microsomal endoribonuclease from rat liver
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980An endoribonuclease has been purified about 320-fold from the microsomes of rat liver. The enzyme had an apparent molecular weight of 54 000-58 000 and produced oligonucleotides, each consisting of 3-7 nucleotides from poly(A) and poly(U). No mononucleotide was obtained by the enzymatic hydrolysis of poly(A) and poly(U) under standard coditions.
Seiyu Hirose +5 more
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Endoribonuclease activities of Trypanosoma brucei mitochondria
Molecular and Biochemical Parasitology, 2002RNA editing in kinetoplastids is a type of post-transcriptional processing that changes mitochondrial mRNA sequences by the addition or deletion of uridines. Multiple enzymatic activities, such as endoribonuclease and RNA ligase, are associated with this process and exist in a multienzyme complex.
Barbara A. Morach +5 more
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European Journal of Biochemistry, 1996
We investigated ribonucleases from Saccharomyces cerevisiae which are active in pre-tRNA 3'-processing in vitro. Two pre-tRNA 3'-exonucleases with molecular masses of 33 and 60 kDa, two pre-tRNA 3'-endonucleases with molecular masses of 45 kDa/60 kDa and
A. Papadimitriou, H. Gross
semanticscholar +1 more source
We investigated ribonucleases from Saccharomyces cerevisiae which are active in pre-tRNA 3'-processing in vitro. Two pre-tRNA 3'-exonucleases with molecular masses of 33 and 60 kDa, two pre-tRNA 3'-endonucleases with molecular masses of 45 kDa/60 kDa and
A. Papadimitriou, H. Gross
semanticscholar +1 more source
Bacteriophage T4 RegB Endoribonuclease
2001Publisher Summary The development of bacteriophage T4 is largely determined by a precisely coordinated subversion of the host RNA polymerase to permit initiation from different classes of T4-specific promoters. The synthesis, in cascade, of regulatory elements that modify the transcription apparatus, ensures the temporal ordering of the developmental
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, 2008
Most patients with acute myeloblastic leukemia (AML) to whom allogeneic stem cell transplantation is unavailable cannot be cured by the standard chemotherapy regimen. Because cytostatic agents used for AML treatment induce damage to DNA of both tumor and
P. Smolewski +8 more
semanticscholar +1 more source
Most patients with acute myeloblastic leukemia (AML) to whom allogeneic stem cell transplantation is unavailable cannot be cured by the standard chemotherapy regimen. Because cytostatic agents used for AML treatment induce damage to DNA of both tumor and
P. Smolewski +8 more
semanticscholar +1 more source
Designing Efficient and Specific Endoribonuclease-Prepared siRNAs
2012RNA interference (RNAi) has grown to be one of the main techniques for loss-of-function studies, leading to the elucidation of biological function of genes in various cellular systems and model organisms. While for many invertebrates such as Drosophila melanogaster (D. melanogaster) and Caenorhabditis elegans (C.
Surendranath V +3 more
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