Results 41 to 50 of about 47,403 (283)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Definitive therapy of colonic angioectasia by submucosal coagulation

Endoscopy International Open, 2019
Background and study aims Colonic angioectasia are the most common vascular lesions in the gastrointestinal tract and are among the most common causes for chronic or recurrent lower gastrointestinal bleeding.
Nagaraj Sriram, Iddo Bar-Yishay, Priyanthi Kumarasinghe, Ian Yusoff, Dev Segarajasingam, Michael J. Bourke, Spiro Raftopoulos   +6 more
doaj   +1 more source

Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience. [PDF]

, 2019
Background and aims  Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America.
Aadam, Abdul Aziz, Aihara, Hiroyuki, Andrawes, Sherif, Benias, Petros, Chang, Kenneth, Diehl, David L, Draganov, Peter V, Hashimoto, Rintaro, Hwang, Joo Ha, Inamdar, Sumant, Khara, Harshit S, Khashab, Mouen A, Khoshknab, Milad Pourmousavi, Kim, Raymond E, Kumta, Nikhil A, Lan, Gloria, Maniere, Thibaut, Natov, Nikola S, Ngamruengphong, Saowanee, Nosler, Michael J, Othman, Mohamed O, Perbtani, Yaseen B, Ramay, Fariha, Samarasena, Jason, Sethi, Amrita, Siegel, Amanda, Tabash, Abdalaziz, Tharian, Benjamin, Tomizawa, Yutaka, Wang, Andrew Y, Yang, Dennis, Zou, Baiming   +31 more
core   +1 more source

Diagnosis and outcome of oesophageal Crohn's disease [PDF]

, 2019
BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement.
Beaton, D, Chaparro, M, Ellul, P, Katsanos, K, Oliveira, AM, et al., Rodrigues, R, Savarino, E, Sladek, M, Teich, N, van der Woude, J, Vavricka, R, Wei, J   +11 more
core   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]

, 2019
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A, Davidson, Nicholas O, Frank, Daniel N, Gathungu, Grace, Li, Ellen, Nelson, Leah M, Robertson, Charles E, Sartor, R. Balfour, Shiekh, Shehzad S, Tian, Xinyu, Wang, Xuefeng, Wolber, Ashley, Zhang, Yuanhao, Zhu, Wei   +13 more
core   +3 more sources

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

Advanced Science, EarlyView.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu, Nhu An Phan, Sy Trung Ngo, Minh Tri Phan, Thanh‐An Truong, Chi Cong Nguyen, Phuoc Thien Phan, Hoang‐Phuong Phan, Thanh Nho Do, Mai Thanh Thai   +9 more
wiley   +1 more source

Noninvasive endoscopic hemostasis technique for post‐papillectomy bleeding using a novel self‐assembling peptide (with video)

JGH Open, 2023
Although a novel hemostatic agent has been used for endoscopic mucosal resection in submucosal dissection, there are few case reports of its use in pancreato‐biliary endoscopic procedures.
Akira Miyano, Takeshi Ogura, Hiroki Nishikawa   +2 more
doaj   +1 more source

Endoscopy : an evolving speciality [PDF]

, 2005
The practice of endoscopy has been rapidly changing due to new emerging technologies and novel techniques. There has been more focus on colonoscopy training with the development of structured programmes including simulators.
Arebi, Naila, Saunders, Brian P., Surgical Procedures, Endoscopic   +2 more
core  

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source