Results 61 to 70 of about 46,605 (211)

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

Surrogate measure of gut blood flow via superior mesenteric circulation on ultrasound in adults who underwent esophagectomy: A descriptive cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Early enteral nutrition is recommended for critically ill patients. However, feeding an ischemic gastrointestinal tract with enteral nutrition may lead to gut necrosis. Although gut tolerance of enteral nutrition is assessed by various symptoms, none of them provide conclusive evidence of gut ischemia. We investigated the blood flow
Tomonori Narita, Kazuhiko Fukatsu, Reo Inoue, Satoshi Murakoshi, Midori Noguchi, Nana Matsumoto, Shoh Yajima, Koichi Yagi, Yoshifumi Baba   +8 more
wiley   +1 more source

Association between specialized nutrition support and 90‐day mortality relative to standard of care in malnourished adults with decompensated cirrhosis: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Malnutrition is common among patients with decompensated liver cirrhosis and linked to poor prognosis. Guidelines recommend intensified nutrition support e.g. parenteral nutrition, but evidence regarding safety and effectiveness is scarce. We aimed to investigate the impact of nutrition support, specifically parenteral nutrition, on
Katharina L. Hupa‐Breier, Laura Buttler, Claudia Seipt, Andrea Markowski, Marie Griemsmann, Tammo L. Tergast, Birgit Kaufmann, Hannah Rieland, Heiner Wedemeyer, Benjamin Maasoumy, Andrea Schneider   +10 more
wiley   +1 more source

Real‐world data on STRIDE‐II treatment targets in a pediatric cohort with inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives STRIDE (selecting therapeutic targets in inflammatory bowel disease) established evidence‐based targets for treat‐to‐target strategies in IBD. STRIDE‐II designates clinical remission, C‐reactive protein (CRP) normalization, and fecal calprotectin (FC) reduction as short‐ to intermediate‐term targets, and mucosal healing as a long ...
Marie‐Luise Frank, Thu Giang Le Thi, Ina Schacker, Lena Bragagna, Milena Geist, Simon Buehler, Victoria Riedl, Sibylle Koletzko, Tobias Schwerd, Hannes Hoelz   +9 more
wiley   +1 more source

Serum aspartate aminotransferase to platelet ratio index in relation to liver histopathology of biliary atresia

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To investigate the prognostic significance of aspartate aminotransferase to platelet ratio index (APRI) in relation to histopathological features across the clinical course of biliary atresia (BA). Methods In this observational cohort study, we enrolled 135 BA patients with available APRI values at Kasai portoenterostomy (KPE, n ...
Nicholas Nordenheim, Iiris Nyholm, Maria Hukkinen, Nelli Sjöblom, Aino Mutka, Jouko Lohi, Mark Davenport, Mikko P. Pakarinen   +7 more
wiley   +1 more source

Double-Balloon Enteroscopy Enhanced With a Magnetic Balloon Anchoring System: A Triple Balloon Novel Approach for Diagnosis and Treatment of Small Bowel Lesions. [PDF]

ACG Case Rep J
Minerba P, Rossi G, Rosa C, Parzanese MI, Alvisi C.   +4 more
europepmc   +1 more source

Risk factors for early postoperative complications after minimally invasive surgery in pediatric ulcerative colitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective To report a single‐center experience with a multidisciplinary minimally invasive surgical approach for pediatric ulcerative colitis (UC) and identify risk factors for early postoperative complications (EPC). Methods A retrospective analysis was conducted on UC patients followed at the Gastroenterology Unit of Meyer Children's ...
Martina Di Benedetto, Luca Scarallo, Sara Renzo, Sara Naldini, Monica Paci, Jacopo Barp, Federico Perna, Emilio Paolo Emma, Riccardo Coletta, Stefano Scaringi, Paolo Lionetti   +10 more
wiley   +1 more source

The Small Bowel's Big Secret: A Case of Hidden Adenocarcinoma Unmasked by Capsule Endoscopy. [PDF]

Cureus
Kiran SK, Hussain R, Raza A, Gul H, Maheshwari P.   +4 more
europepmc   +1 more source