Results 51 to 60 of about 24,168 (116)

Beyond the Secretory Pathway: New Insights Into Protein Release

Traffic, Volume 26, Issue 10-12, October/December 2025.
While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen, Antonio J. Costa‐Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, Vassiliki Nikoletopoulou, Stacey K. Ogden, Georgia Maria Sagia, Feng Shao, Anbing Shi, Clotilde Thery, Christel Vérollet, Julien Villeneuve, Frederik Verweij, Yanzhuang Wang, Juan Wang, Shenjie Wu, Yihong Ye, Hang Yin, Li Yu, Min Zhang, Ying Zhang, Xin Zhou, Chiara Zurzolo   +34 more
wiley   +1 more source

Microautophagy in the Yeast Saccharomyces cerevisiae

, 2008
Microautophagy involves direct invagination and fission of the vacuolar/lysosomal membrane under nutrient limitation. In Saccharomyces cerevisiae microautophagic uptake of soluble cytosolic proteins occurs via an autophagic tube, a highly specialized ...
Andreas Uttenweiler, Andreas Mayer, Uttenweiler, A., Mayer, A.   +3 more
core   +1 more source

Extracellular Vesicles in Arthropods: Biogenesis, Functions, Isolation Methods and Applications

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound nanoparticles secreted by cells that are involved in multiple forms of intercellular communication and show promising potential for biotechnological applications. Arthropod‐derived EV research remains relatively fragmented in contrast to the extensively studied mammalian EV field. In this review,
Simon Remans, Stijn Van den Brande, Jozef Vanden Broeck, Dulce Santos   +3 more
wiley   +1 more source

Hsc70-4 deforms membranes to promote synaptic protein turnover by endosomal microautophagy

, 2016
Synapses are often far from their cell bodies and must cope largely independently with dysfunctional proteins resulting from synaptic activity and stress.
Maes, Ine
core  

ESCRT and autophagies: Endosomal functions and beyond

, 2018
International audienceESCRT (endosomal sorting complex required for transport) machinery has been initially identified for its role during endocytosis, which allows membrane proteins and lipids to be degraded in the lysosome.
Christophe Lefebvre, Legouis, Renaud, Culetto, Emmanuel, Emmanuel Culetto, Lefebvre, Christophe, Renaud Legouis   +5 more
core   +1 more source

Evidence that mitochondria in macrophages are destroyed by microautophagy. [PDF]

Nat Commun
Lu S.L., Chen S., Noda K., et al. Evidence that mitochondria in macrophages are destroyed by microautophagy. Nature Communications 16, 8123 (2025); https://doi.org/10.1038/s41467-025-63531-x.Microautophagy is an intracellular degradation process in which
Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T.   +18 more
europepmc   +3 more sources

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, Volume 5, Issue 6, June 2025.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Clearance Pathways for α‐Synuclein in Parkinson's Disease

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
α‐syn degradation in neurons and glia in PD. (A) Monomeric or prefibrillar α‐syn is eliminated in neurons via the UPS pathway. Under pathological conditions, fibrillar α‐syn is targeted by autophagy, while CMA is the major route for monomeric or prefibrillar α‐syn.
Margaret S. Ho
wiley   +1 more source

Proteasome activity and endosomal microautophagy are unaffected in Gba1b mutants.

, 2018
(A) Measurement of proteasome activity from fly heads using fluorescent substrates, normalized to total protein, in Gba1b mutants and controls. Nonproteasomal (epoxomicin-insensitive) background activity was subtracted. Error bars represent SEM.
Gennifer E. Merrihew (2794255), Michael J. MacCoss (125430), Marie Y. Davis (2577166), Leo J. Pallanck (569511), Evelyn S. Vincow (250686), Ruth E. Thomas (250683)   +5 more
core   +1 more source

Chapter 11 Cell‐Free Reconstitution of Microautophagy in Yeast

, 2008
Microautophagy is the direct uptake of soluble or particulate cellular constituents into lysosomes. Here, I describe methods to reconstitute and study this process in vitro, using vacuoles (lysosomes) from the yeast Saccharomyces cerevisiae as model ...
Andreas Mayer, Mayer, A.
core   +1 more source