Results 131 to 140 of about 7,550 (174)
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Endostatin inhibits endochondral ossification
The Journal of Gene Medicine, 2007AbstractBackgroundAngiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. Vascular endothelial growth factor‐A (VEGF‐A) is a key regulator of angiogenesis whereas endostatin, a potent inhibitor of endothelial cell proliferation and migration, is a natural antagonist of VEGF‐A.
A, Sipola +8 more
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Variable zinc coordination in endostatin
Journal of Molecular Biology, 2000Endostatin is a proteolytic fragment of collagen XVIII that potently inhibits angiogenesis and tumour growth. Human endostatin contains a zinc ion, bound near the N terminus, which was not observed in the original structure of mouse endostatin at pH 5. Controversial data exist on the role of this zinc ion in the anti-tumour activity.
E, Hohenester +3 more
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2002
The generation of endogenous inhibitors of angiogenesis that are specific for endothelial cells from larger precursor molecules with entirely different functions, appears to be a recurrent theme. Early reports on such a novel class of inhibitors came from the study of the 16 kDa fragment of prolactin (1,2),and the 29 kDa heparin-binding fragment of ...
Jesus V. Soriano, B. Kim Lee Sim
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The generation of endogenous inhibitors of angiogenesis that are specific for endothelial cells from larger precursor molecules with entirely different functions, appears to be a recurrent theme. Early reports on such a novel class of inhibitors came from the study of the 16 kDa fragment of prolactin (1,2),and the 29 kDa heparin-binding fragment of ...
Jesus V. Soriano, B. Kim Lee Sim
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Endostatin: The logic of antiangiogenic therapy
Drug Resistance Updates, 2005The hypothesis that tumor growth and metastasis is angiogenesis-dependent was proposed by Judah Folkman in 1971. Its major implication is that blocking angiogenesis could be a strategy for arresting tumor growth. This hypothesis is now supported by extensive experimental evidence, and hence the angiogenic switch and microvascular endothelial cells ...
Amir, Abdollahi +2 more
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Influence of endostatin on embryonic vasculo‐ and angiogenesis
Developmental Dynamics, 2004AbstractThe proteolytic fragment of collagen XVIII, endostatin, acts as an inhibitor of angiogenesis. To date, only limited knowledge exists on the effects of endostatin on endothelial cells during embryonic development. Therefore, we analysed the role of endostatin on embryonic vasculo‐ and angiogenesis.
Schmidt, A. +9 more
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IDrugs : the investigational drugs journal, 2005
EntreMed has licensed the worldwide rights to the angiogenesis inhibitor Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, from the Children's Hospital of Boston, a teaching affiliate of Harvard Medical School. It is being developed as a potential cancer treatment and may also be useful in certain types of blindness and arthritis [227427 ...
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EntreMed has licensed the worldwide rights to the angiogenesis inhibitor Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, from the Children's Hospital of Boston, a teaching affiliate of Harvard Medical School. It is being developed as a potential cancer treatment and may also be useful in certain types of blindness and arthritis [227427 ...
openaire +1 more source