Results 1 to 10 of about 343,895 (162)

Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin [PDF]

ChemistryOpen, 2022
Following the successful introduction of two benign solvents for cleaving protected acid peptide fragments from 2‐chlorotrityl chloride (2‐CTC) resin, there is a need to green the cleavage process for obtaining protected peptide amide fragments.
Dr. Othman Al Musaimi, Varshitha Gavva, Prof. Dr. Daryl R. Williams   +2 more
doaj   +3 more sources

Comparative studies for amyloid beta degradation: “Neprilysin vs insulysin”, “monomeric vs aggregate”, and “whole Aβ40 vs its peptide fragments” [PDF]

Biochemistry and Biophysics Reports, 2022
Amyloid beta (Aβ) proteins are produced from amyloid precursor protein cleaved by β- and γ-secretases, and are the main components of senile plaques pathologically found in Alzheimer's disease (AD) patient brains.
Dai Kato, Yoshiaki Takahashi, Haruto Iwata, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe   +5 more
doaj   +2 more sources

Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ [PDF]

Scientific Reports, 2021
Amyloid β (Aβ) peptide aggregation plays a central role in Alzheimer’s disease (AD) etiology. AD drug candidates have included small molecules or peptides directed towards inhibition of Aβ fibrillogenesis.
Faisal Abedin, Nabin Kandel, Suren A. Tatulian   +2 more
doaj   +2 more sources

Tracking the Amide I and αCOO− Terminal ν(C=O) Raman Bands in a Family of l-Glutamic Acid-Containing Peptide Fragments: A Raman and DFT Study [PDF]

Molecules, 2021
The E-hook of β-tubulin plays instrumental roles in cytoskeletal regulation and function. The last six C-terminal residues of the βII isotype, a peptide of amino acid sequence EGEDEA, extend from the microtubule surface and have eluded characterization ...
Ashley E. Williams, Nathan I. Hammer, Ryan C. Fortenberry, Dana N. Reinemann   +3 more
doaj   +2 more sources

Anticancer properties of peptide fragments of hair proteins. [PDF]

PLoS ONE, 2014
The primary function of hair and fur covering mammalian skin is to provide mechanical and thermal protection for the body. The proteins that constitute hair are extremely resistant to degradation by environmental factors.
Sergiusz Markowicz, Joanna Matalinska, Katarzyna Kurzepa, Marta Bochynska, Marzena Biernacka, Anna Samluk, Dorota Dudek, Henryk Skurzak, Masaaki Yoshikawa, Andrzej W Lipkowski   +9 more
doaj   +2 more sources

Chlorotoxin does not target matrix metalloproteinase-2 in glioblastoma. [PDF]

PLoS ONE
Glioblastoma aggressively invades surrounding tissue by expressing matrix metalloproteinase-2 (MMP-2). Therefore, effective inhibition of MMP-2 is a desirable target for treatment.
Eli Blaney, Meron Demeke, Seraphine Kamayirese, Louise Monga, Laura A Hansen, Charles R Watts, Sándor Lovas   +6 more
doaj   +2 more sources

Antimicrobial Peptide Designing and Optimization Employing Large-Scale Flexibility Analysis of Protein-Peptide Fragments [PDF]

ACS Omega, 2019
Neeraj Kumar, Damini Sood, Ravi Tomar, Ramesh Chandra   +3 more
doaj   +2 more sources

Peptide Extracts from Seven Medicinal Plants Discovered to Inhibit Oomycete Phytophthora infestans, a Causative Agent of Potato Late Blight Disease

Plants, 2020
We report the inhibitory effect of peptide extracts obtained from seven medicinal plants against a causative agent of late blight disease Phytophthora infestans.
Eugene A. Rogozhin, Alexey S. Vasilchenko, Anna S. Barashkova, Alexey N. Smirnov, Sergey K. Zavriev, Vladimir P. Demushkin   +5 more
doaj   +1 more source

Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations

Molecules, 2022
Data from the World Health Organisation show that the global incidence of dengue infection has risen drastically, with an estimated 400 million cases of dengue infection occurring annually.
Norburhanuddin Johari Zaidi, Adib Afandi Abdullah, Choon Han Heh, Chun-Hung Lin, Rozana Othman, Abdullah Al Hadi Ahmad Fuaad   +5 more
doaj   +1 more source

Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models

Biomolecules, 2020
Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three β-structural loops, similarly to snake venom α-neurotoxin TFPs.
Konstantin S. Mineev, Elena V. Kryukova, Igor E. Kasheverov, Natalia S. Egorova, Maxim N. Zhmak, Igor A. Ivanov, Dmitry A. Senko, Alexey V. Feofanov, Anastasia A. Ignatova, Alexander S. Arseniev, Yuri N. Utkin, Victor I. Tsetlin   +11 more
doaj   +1 more source