Comparative studies for amyloid beta degradation: "Neprilysin vs insulysin", "monomeric vs aggregate", and "whole Aβ40 vs its peptide fragments". [PDF]
Biochem Biophys Rep, 2022 Amyloid beta (Aβ) proteins are produced from amyloid precursor protein cleaved by β- and γ-secretases, and are the main components of senile plaques pathologically found in Alzheimer's disease (AD) patient brains.
Kato D +5 more
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Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin. [PDF]
ChemistryOpen, 2022 Following the successful introduction of two benign solvents for cleaving protected acid peptide fragments from 2‐chlorotrityl chloride (2‐CTC) resin, there is a need to green the cleavage process for obtaining protected peptide amide fragments.
Al Musaimi O, Gavva V, Williams DR.
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Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ. [PDF]
Sci Rep, 2021 Amyloid β (Aβ) peptide aggregation plays a central role in Alzheimer’s disease (AD) etiology. AD drug candidates have included small molecules or peptides directed towards inhibition of Aβ fibrillogenesis.
Abedin F, Kandel N, Tatulian SA.
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Tracking the Amide I and αCOO- Terminal ν(C=O) Raman Bands in a Family of l-Glutamic Acid-Containing Peptide Fragments: A Raman and DFT Study. [PDF]
Molecules, 2021 The E-hook of β-tubulin plays instrumental roles in cytoskeletal regulation and function. The last six C-terminal residues of the βII isotype, a peptide of amino acid sequence EGEDEA, extend from the microtubule surface and have eluded characterization ...
Williams AE +3 more
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Anticancer properties of peptide fragments of hair proteins. [PDF]
PLoS One, 2014 The primary function of hair and fur covering mammalian skin is to provide mechanical and thermal protection for the body. The proteins that constitute hair are extremely resistant to degradation by environmental factors.
Markowicz S +9 more
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A Model of Demasking and Hydrolysis of Peptide Bonds During Tryptic Digestion of β-Casein and β-Lactoglobulin. [PDF]
MoleculesThe prediction of polypeptide chain fragmentation during digestion (proteolysis) of protein substrates by trypsin was carried out for globular β-lactoglobulin (β-LG) and micellar β-casein (β-CN).
Vorob'ev MM.
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Chlorotoxin does not target matrix metalloproteinase-2 in glioblastoma. [PDF]
PLoS OneGlioblastoma aggressively invades surrounding tissue by expressing matrix metalloproteinase-2 (MMP-2). Therefore, effective inhibition of MMP-2 is a desirable target for treatment.
Blaney E +6 more
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Antimicrobial Peptide Designing and Optimization Employing Large-Scale Flexibility Analysis of Protein-Peptide Fragments. [PDF]
ACS Omega, 2019 Kumar N +4 more
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Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]
, 2012 Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Antonia Vlahou +43 more
core +11 more sources
Signature Fragment Ions of Biotinylated Peptides [PDF]
Journal of the American Society for Mass Spectrometry, 2020 The use of biotin or biotin-containing reagents is an essential component of many protein purification and labeling technologies. Owing to its small size and high affinity to the avidin family of proteins, biotin is a versatile molecular handle that permits both enrichment and purity that is not easily achieved by other reagents. Traditionally, the use
Santosh Renuse +12 more
openaire +3 more sources