Results 31 to 40 of about 355,998 (353)
The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release. [PDF]
PLoS ONE, 2018 Major Histocompatibility Complex class II (MHC-II) molecules bind peptides and present them to receptors on CD4+ T cells as part of the immune system's surveillance of pathogens and malignancy.
Maria Pia Negroni, Lawrence J Stern
doaj +1 more source
Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy
Medicine in Drug Discovery, 2020 Immune system regained the attention of oncologists and has entered the mainstream for cancer therapy since the discovery of checkpoint antibodies targeting CTLA4 and PD-1 pathways.
Pottayil G. Sasikumar +1 more
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From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs
Frontiers in Pharmacology, 2019 The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin ...
Elena V. Kryukova +11 more
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Algorithms for the analysis of MALDI peptide mass fingerprint spectra for proteomics [PDF]
, 2005 In this study we present a simple algorithm which allows accurate estimates of the similarity between peptide fingerprint mass spectra from matrix assisted laser desorption/ionization (MALDI) spectrometers.
Monigatti, Flavio
core +1 more source
PLoS ONE, 2015 Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase liberates highly potent circulating heparan sulfate-fragments (HS-fragments) and triggers the fatal and excessive inflammatory ...
Lukas Martin +8 more
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Protein GB1 folding and assembly from structural elements. [PDF]
, 2009 Folding of the Protein G B1 domain (PGB1) shifts with increasing salt concentration from a cooperative assembly of inherently unstructured subdomains to an assembly of partly pre-folded structures.
Xue, Wei-Feng +6 more
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Proteomes, 2021 Non-invasive urinary peptide biomarkers are able to detect and predict chronic kidney disease (CKD). Moreover, specific urinary peptides enable discrimination of different CKD etiologies and offer an interesting alternative to invasive kidney biopsy ...
Lorenzo Catanese +6 more
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Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) [PDF]
, 2009 Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC).
Patil, Rahul D. +17 more
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MethodsX, 2021 The semenogelin 1 protein is secreted in the seminal vesicles. After ejaculation it is split into small peptide fragments using internal proteases.
Aydar Bikmullin +3 more
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A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments
, 2022 Discovery of protein-binding fragments for precisely defined binding sites is an unmet challenge so far. Here, we investigate formylglycine as a molecular probe for the sensitive detection of fragments binding to a spatially defined protein site ...
Christoph, Arkona +8 more
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