Results 31 to 40 of about 355,483 (262)

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are:•Simple.•Low cost.•Solid phase based.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
openaire   +3 more sources

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. [PDF]

PLoS ONE, 2014
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS.
Kalyan C Tirupula, Russell Desnoyer, Robert C Speth, Sadashiva S Karnik   +3 more
doaj   +1 more source

Signature Fragment Ions of Biotinylated Peptides [PDF]

Journal of the American Society for Mass Spectrometry, 2020
The use of biotin or biotin-containing reagents is an essential component of many protein purification and labeling technologies. Owing to its small size and high affinity to the avidin family of proteins, biotin is a versatile molecular handle that permits both enrichment and purity that is not easily achieved by other reagents. Traditionally, the use
Santosh Renuse, Anil K. Madugundu, Jae Hun Jung, Seul Kee Byeon, Hana L. Goldschmidt, Raiha Tahir, David Meyers, Dae In Kim, Jevon Cutler, Kwang Pyo Kim, Xinyan Wu, Richard L. Huganir, Akhilesh Pandey   +12 more
openaire   +3 more sources

A peptide filtering relation quantifies MHC class I peptide optimization.

PLoS Computational Biology, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Neil Dalchau, Andrew Phillips, Leonard D Goldstein, Mark Howarth, Luca Cardelli, Stephen Emmott, Tim Elliott, Joern M Werner   +7 more
doaj   +1 more source

Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases

Brazilian Journal of Medical and Biological Research, 1999
Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases.
L.H.B. Boechat, R.L. Zollner
doaj   +1 more source

Chronological Profiling of Plasma Native Peptides after Hepatectomy in Pigs: Toward the Discovery of Human Biomarkers for Liver Regeneration. [PDF]

PLoS ONE, 2017
Liver regeneration after partial hepatectomy (PHx) is a time-dependent process, which is tightly regulated by multiple signaling cascades. Failure of this complex process leads to posthepatectomy liver failure (PHLF), which is associated with a high rate
Kohta Iguchi, Etsuro Hatano, Takashi Nirasawa, Noriyuki Iwasaki, Motohiko Sato, Gen Yamamoto, Kenya Yamanaka, Tatsuya Okamoto, Yosuke Kasai, Naohiko Nakamura, Hiroaki Fuji, Tomohito Sakai, Nobuto Kakuda, Satoru Seo, Kojiro Taura, Kei Tashiro, Shinji Uemoto, Masaya Ikegawa   +17 more
doaj   +1 more source

Mapping of residues of fibrinogen cleaved by protease II of Bacillus thuringiensis var. israelensis IMV B-7465 [PDF]

The Ukrainian Biochemical Journal, 2016
The limited proteolysis of macromolecules allows obtaining the fragments that preserve the structure and functional properties of the whole molecule and could be used in the study of proteins structure and function.
E. M. Stohniy, V. O. Chernyshenko, N. A. Nidialkova, A. V. Rebriev, L. D. Varbanets, V. E. Hadzhynova, T. M. Chernyshenko, I. M. Kolesnikova, E. V. Lugovskoy   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Immunomodulatory and neurotropic activities of synthetic peptides in a model of brain injury in rats

Медицинская иммунология, 2023
Treatment of consequences of traumatic brain injury (TBI) remains one of the current problems of medicine. To increase the effectiveness of treatment of post-traumatic complications, various drugs are recommended, including the peptide with ...
N. B. Serebryanaya, S. N. Shanin, T. A. Filatenkova, E. E. Fomicheva, A. S. Komlev, O. V. Shamova   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source