Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. [PDF]
PLoS ONE, 2014 MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS.
Kalyan C Tirupula +3 more
doaj +1 more source
Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]
, 2020 Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita +10 more
core
Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups [PDF]
, 2017 Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions.
Gaya, Daniel +9 more
core +2 more sources
A peptide filtering relation quantifies MHC class I peptide optimization.
PLoS Computational Biology, 2011 Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Neil Dalchau +7 more
doaj +1 more source
Functional Divergence of Glycoprotein Hormone Receptors [PDF]
, 2010 Two lamprey glycroprotein hormone receptors (lGpH-R I and II) highly similar with gnathostome GpH-Rs were cloned from sea lamprey testes and thyroid, respectively.
Freamat, Mihael, Sower, Stacia A.
core +3 more sources
Brazilian Journal of Medical and Biological Research, 1999 Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases.
L.H.B. Boechat, R.L. Zollner
doaj +1 more source
Temperature-sensitive protein–DNA dimerizers [PDF]
, 2005 Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an ...
Ansari, Aseem Z. +6 more
core +1 more source
Chronological Profiling of Plasma Native Peptides after Hepatectomy in Pigs: Toward the Discovery of Human Biomarkers for Liver Regeneration. [PDF]
PLoS ONE, 2017 Liver regeneration after partial hepatectomy (PHx) is a time-dependent process, which is tightly regulated by multiple signaling cascades. Failure of this complex process leads to posthepatectomy liver failure (PHLF), which is associated with a high rate
Kohta Iguchi +17 more
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Antigenic Determinant of Trichosanthin Peptide Fragments
Immunopharmacology and Immunotoxicology, 1986 Purified plant protein, Trichosanthin (TCS), was partially digested with chymotrypsin to produce peptide fragments. Two large fragments, I and II, have been isolated and identified as C-terminal peptides located at sequence positions between 79-234 and 107-234. Their molecular weights determined by electrophoretic mobility on SDS gel were 16,000 and 14,
Y P, Ke, Y H, Wang, Z, Yao, K M, Wang
openaire +2 more sources
Mapping of residues of fibrinogen cleaved by protease II of Bacillus thuringiensis var. israelensis IMV B-7465 [PDF]
The Ukrainian Biochemical Journal, 2016 The limited proteolysis of macromolecules allows obtaining the fragments that preserve the structure and functional properties of the whole molecule and could be used in the study of proteins structure and function.
E. M. Stohniy +8 more
doaj +1 more source