Results 41 to 50 of about 355,998 (353)
Nature Communications, 2022 Peptide fragments derived from the interfaces of protein-protein interactions (PPIs) provide useful templates for designing small molecule PPI inhibitors.
Xiyao Cheng +8 more
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Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are:•Simple.•Low cost.•Solid phase based.
Yuxuan Dai +3 more
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Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling
, 2023 Growth differentiation factor 15 (GDF15) is believed to be a major causative factor for cancer-induced cachexia. Recent elucidation of the central circuits involved in GDF15 function and its signaling through the glial cell-derived neurotrophic factor ...
Fink, Lisbeth Nielsen +11 more
core +1 more source
Modeling peptide fragmentation with dynamic Bayesian networks for peptide identification [PDF]
Bioinformatics, 2008 AbstractMotivation: Tandem mass spectrometry (MS/MS) is an indispensable technology for identification of proteins from complex mixtures. Proteins are digested to peptides that are then identified by their fragmentation patterns in the mass spectrometer.
Aaron A. Klammer +4 more
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Collisional energy dependence of peptide ion fragmentation [PDF]
Journal of the American Society for Mass Spectrometry, 2009 The energy dependence of fragmentation in a collision cell was measured for 2400 protonated peptide ions derived from the digestion of 24 proteins. The collision voltage at which the sum of the fragment ion abundances was equal to the remaining parent ion (V(1/2)) was the principal measure of fragmentation effectiveness.
Neta, Pedatsur +3 more
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Light-Induced Orthogonal Fragmentation of Crosslinked Peptides
JACS Au, 2023 Crosslinking mass spectrometry provides pivotal information on the structure and interaction of proteins. MS-cleavable crosslinkers are regarded as a cornerstone for the analysis of complex mixtures. Yet they fragment under similar conditions as peptides, leading to mixed fragmentation spectra of the crosslinker and peptide.
Lars Kolbowski +4 more
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Differential patterns of PMN-elastase and type III procollagen peptide in knee joint effusions due to acute and chronic sports injuries [PDF]
, 1991 In 38 traumatic knee joint effusions the proteolytic enzyme PMN-elastase (PMN-E) and the repair marker procollagen III aminoterminal peptide (PIIINP) were determined.
Bernett, P. +3 more
core +1 more source
Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. [PDF]
PLoS ONE, 2014 MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS.
Kalyan C Tirupula +3 more
doaj +1 more source
Effect of phenylalanine on the fragmentation of deprotonated peptides [PDF]
Journal of the American Society for Mass Spectrometry, 2002 The fragmentation reactions of a variety of deprotonated dipeptides and tripeptides containing phenylalanine have been studied using energy-resolved collision-induced dissociation, isotopic labeling and MS/MS/MS experiments. The benzyl a-group has a substantial effect on the fragmentation reactions observed.
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Peptide fragmentation induced by radicals at atmospheric pressure [PDF]
Journal of Mass Spectrometry, 2008 AbstractA novel ion dissociation technique, which is capable of providing an efficient fragmentation of peptides at essential atmospheric pressure conditions, is developed. The fragmentation patterns observed often contain c‐type fragments that are specific to electron capture dissociation/electron transfer dissociation (ECD/ETD), along with the y‐/b ...
Andrey N, Vilkov +2 more
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