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Platelet-derived endothelial cell growth factor
Progress in Growth Factor Research, 1991AbstractPlatelet‐derived endothelial cell growth factor (PD‐ECGF) is a 45kDa single chain polypeptide which stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. Analysis of a full length PD‐ECGF cDNA revealed an open reading frame coding for 482 amino acids without homology to other known proteins. No signal sequence was
K, Miyazono, K, Usuki, C H, Heldin
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Vascular endothelial growth factor
The International Journal of Biochemistry & Cell Biology, 1998Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis in development, in cancer and in other important diseases. VEGF regulates multiple endothelial cell functions including mitogenesis, permeability, vascular tone, and the production of vasoactive molecules.
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Growth factors in endothelial regeneration
Cardiovascular Research, 199381902
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Vascular Endothelial Growth Factor and Angiogenesis
Pharmacological Reviews, 2004Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for
Ann, Hoeben +5 more
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Frontiers in Bioscience, 2007
Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo, Cai, Xiaoyuan, Chen
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Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo, Cai, Xiaoyuan, Chen
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Vascular Endothelial Growth Factor in Cervical Carcinoma
Obstetrics & Gynecology, 1999To quantitate vascular endothelial growth factor of cervical carcinoma and elucidate its clinical correlation.Intratumoral protein levels of vascular endothelial growth factor were measured in 104 cervical cancer patients and in 30 cervical tissue specimens of benign gynecologic diseases as controls. The concentrations were correlated with clinical and
W F, Cheng +5 more
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Vascular Endothelial Growth Factor and its Receptors
Retina, 1994Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells and an angiogenic factor that is structurally related to platelet derived growth factor (PDGF). It is also known as the vascular permeability factor (VPF) because it efficiently potentiates the permeabilization of blood vessels. Five types of VEGF mRNA
G, Neufeld +4 more
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Vascular Endothelial Growth Factor Receptor-3
1999Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine ...
J, Taipale +5 more
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Antivascular Endothelial Growth Factor in Diabetic Retinopathy
2010Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) represent the most common causes of vision loss in patients affected by diabetes mellitus. Diabetic retinopathy (DR) needs special attention because of its high public health impact and impact on quality of life of patients.
Iacono P +2 more
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