Results 91 to 100 of about 23,747,035 (396)

Activin A‐activated ALK4 induces pathogenic Th17 involved endothelial–mesenchymal transition in systemic lupus erythematosus‐associated pulmonary arterial hypertension

Arthritis &Rheumatology, Accepted Article.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE, has not been clarified.
Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J Bogaard, Lie Wang, Mengtao Li, Jun Yang   +9 more
wiley   +1 more source

Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]

, 2006
Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A., Rankin, A.C., Redpath, C., Workman, A.J.   +3 more
core   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction

International Journal of Vascular Medicine, 2020
Introduction. Serum endothelin-1 is increasingly released in acute myocardial infarction, by necrotic cardiomyocytes. In non-ST-elevation acute myocardial infarction (Non-STEMI), increased serum endothelin-1 on-admission may have clinical significance ...
Anggoro Budi Hartopo, Indah Sukmasari, Ira Puspitawati, Budi Yuli Setianto   +3 more
doaj   +1 more source

Endothelin-1 expression in prostate needle biopsy specimens correlated with aggressiveness of prostatic cancer [PDF]

Iranian Journal of Pathology, 2017
Background & Objective: As the prostate adenocarcinoma is one of the most common malignant tumors in males, looking for a marker to effectively predict aggressiveness and metastatic potential in an apparently localized cancer in initial needle biopsy ...
Mojgan Asgari, Elham Eftekhar, Maryam Abolhasani, Hossein Shahrokh   +3 more
doaj   +1 more source

Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2014
Background Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops and worsens pathologically and clinically in terms of the genetic–environmental interactions ...
Atsushi Tanaka, S. Yuasa, G. Mearini, Toru Egashira, Tomohisa Seki, Masaki Kodaira, D. Kusumoto, Yusuke Kuroda, Shinichiro Okata, Tomoyuki Suzuki, T. Inohara, T. Arimura, S. Makino, Kensuke Kimura, A. Kimura, T. Furukawa, L. Carrier, K. Node, K. Fukuda   +18 more
semanticscholar   +1 more source

Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach

Journal of Pharmacological Sciences, 2003
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura, Shoshiro Okada, Kunihiko Yokotani   +2 more
doaj  

Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Background Elevated high blood pressure is controlled by complicated, little‐understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure‐related genomic loci have been identified through previous genome‐wide association
Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny N. M. Soetedjo   +7 more
wiley   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed, Ando, Anthony P. Davenport, Battistini, Bayes, Bucchwalder-Csajka, Chen, Christopher Hillier, D'Orleans-Juste, Davenport, Davenport, Davenport, Dhaun, Dickstein, Dive, Emoto, Favrat, Fecteau, Ferro, Fiona Johnston, Flather, Garg, Hand, Hanka J. de Voogd, Hans Essers, Haynes, Haynes, Janet J. Maguire, Jardine, John McMurray, Johnstrom, Kentsch, Ling, Love, Maguire, Maguire, Maguire, McDonagh, McDowell, Naruse, Newby, Northridge, Northridge, O'Connell, Palmer, Plumpton, Rhoda E. Kuc, Richards, Richards, Richards, Rousso, Russell, Russell, Russell, Russell, Schirger, Tabrizchi, Thöne-Reinke, Vachiéry, Van der Meer, Xu, Yanagisawa, Yusuf   +62 more
core   +2 more sources

Endothelin-1 activity in pregnancy

Journal of Obstetrics and Gynaecology, 2002
Plasma endothelin-1 activity was measured by radioimmunoassay in 24 normotensive non-pregnant women and in 24 normotensive pregnant, 24-aproteinuric hypertensive and 24 pre-eclamptic women. Endothelin-1 activity was increased in the pre-eclamptic group (2.7 +/- 06 pg/ml) compared to the normotensive non-pregnant (1.0 +/- 0.8 pg/ml; P < 0.0001 ...
S M Khedun, J. Moodley, T. Naicker
openaire   +3 more sources