Results 91 to 100 of about 24,309,158 (381)

Potential Role of Ultrafine Particles in Associations between Airborne Particle Mass and Cardiovascular Health [PDF]

, 2005
Numerous epidemiologic time-series studies have shown generally consistent associations of cardiovascular hospital admissions and mortality with outdoor air pollution, particularly mass concentrations of particulate matter (PM) ≤2.5 or ≤10 μm in diameter
Constantinos Sioutas, Desai MM, Diaz-Sanchez D, Godleski JJ, MacNee W, McGrath JJ, Pekkanen J, Ralph J. Delfino, Rifai N, Samet JM, Schreck R, Shaista Malik, Wichmann HE   +12 more
core   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Endothelin-1 in Congenital Heart Disease [PDF]

Pediatric Research, 2005
Endothelin-1 (ET-1) is a 21-amino acid polypeptide produced primarily by vascular endothelial cells. First discovered in 1988 as a potent vasoconstrictor, it has subsequently been appreciated to participate in several biologic activities, including vascular smooth muscle proliferation, fibrosis, cardiac and vascular hypertrophy, and inflammation ...
Beghetti, Maurice, Black, Stephen M, Fineman, Jeffrey R   +2 more
openaire   +2 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Cerebral perfusion and its association with serum endothelin-1 in multiple sclerosis [PDF]

, 2022
Azza Bayoumi Hammad, Eman Mohammed Seif El Din, Ghada Saed Abdel Azim, Mohamed Ali Abboud   +3 more
openalex   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]

, 2018
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura, D’Amato, Andrea, Fedele, Francesco, Mancone, Massimo, Netti, Lucrezia, Palmirotta, Raffaele, Pucci, Mariateresa, Severino, Paolo, Volterrani, Maurizio   +8 more
core   +2 more sources

Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction

International Journal of Vascular Medicine, 2020
Introduction. Serum endothelin-1 is increasingly released in acute myocardial infarction, by necrotic cardiomyocytes. In non-ST-elevation acute myocardial infarction (Non-STEMI), increased serum endothelin-1 on-admission may have clinical significance ...
Anggoro Budi Hartopo, Indah Sukmasari, Ira Puspitawati, Budi Yuli Setianto   +3 more
doaj   +1 more source

Endothelin-1 (1-31) Is an Intermediate in the Production of Endothelin-1 After Big Endothelin-1 Administration In Vivo [PDF]

Hypertension, 2005
The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the rabbit in vivo.
Marie-Hélène, Fecteau, Jean-Claude, Honoré, Mirco, Plante, Julie, Labonté, Giles A, Rae, Pedro, D'Orléans-Juste   +5 more
openaire   +2 more sources

Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2014
Background Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops and worsens pathologically and clinically in terms of the genetic–environmental interactions ...
Atsushi Tanaka, S. Yuasa, G. Mearini, Toru Egashira, Tomohisa Seki, Masaki Kodaira, D. Kusumoto, Yusuke Kuroda, Shinichiro Okata, Tomoyuki Suzuki, T. Inohara, T. Arimura, S. Makino, Kensuke Kimura, A. Kimura, T. Furukawa, L. Carrier, K. Node, K. Fukuda   +18 more
semanticscholar   +1 more source