Results 121 to 130 of about 21,304,051 (308)

Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

Neural Regeneration Research
[INLINE:1] Vascular etiology is the second most prevalent cause of cognitive impairment globally. Endothelin-1, which is produced and secreted by endothelial cells and astrocytes, is implicated in the pathogenesis of stroke.
Jie Li, Wen Jiang, Yuefang Cai, Zhenqiu Ning, Yingying Zhou, Chengyi Wang, Sookja Ki Chung, Yan Huang, Jingbo Sun, Minzhen Deng, Lihua Zhou, Xiao Cheng   +11 more
doaj   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Endothelin-1 in the regulation of vascular function and glucose metabolism in insulin resistance

, 2010
Insulin resistance plays a major role in the pathogenesis of type 2 diabetes and is an important risk factor for cardiovascular disease. Endothelial dysfunction, characterized by reduced bioactivity of nitric oxide and increased activity of the ...
Alexey Shemyakin (18663223)
core  

The [Lys^-2-Arg^-1-des(17−21)]-Endothelin-1 Peptide Retains the Specific Arg^-1−Asp⁸ Salt Bridge but Reveals Discrepancies between NMR Data and Molecular Dynamics Simulations^†

, 2016
The [des(17−21)]-endothelin-1 (CSH-ET) and [Lys-2-Arg-1-des(17−21)]-endothelin-1 (KR-CSH-ET) peptides, designed by removing the five-residue hydrophobic tail from the endothelin-1 (ET-1) and [Lys-2-Arg-1]-endothelin-1 (KR-ET-1) peptides, respectively ...
Laurent Chiche (6463), Quentin Kaas (26864), André Aumelas (2504917), Yuji Kobayashi (633477), Naoyoshi Chino (2947002), Shigeru Kubo (2947005)   +5 more
core   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu

, 2009
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Noriko N. Okada, Yasuhiro Tsukamoto, Masaki M. Imai, Kazuhide K. Adachi, Retno Damajanti R. D. Soejoedono, Alan A. Okada, Hidechika H. Okada, Ekowati E. Handharyani   +7 more
core  

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Mediadores envolvidos na nocicepção, hiperalgesia e edema causados pela endotelina-1 em camundongos: [dissertação] [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Farmacologia.O presente estudo investigou os mecanismos celulares e mediadores envolvidos nas respostas nociceptiva ...
Frighetto, Mônica
core  

Triptolide capsule enables proteinuria reduction and renal stabilization in advanced alport syndrome beyond standard therapy

Rheumatology &Autoimmunity, EarlyView.
Zhuo‐ran Song, Na Li, Yang Li, Hong Zhang, Xu‐jie Zhou   +4 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source