Results 191 to 200 of about 21,304,051 (308)

Adropin and Endothelin-1 as Complementary Signals Associated with Early Vascular Aging in Middle-Aged Type 2 Diabetes. [PDF]

Diseases
Sivakumar R, Aravaanan ASK, Mohanakrishnan VV, Kumar J.   +3 more
europepmc   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

The correlation between serum endothelin-1 levels and aortic stiffness in patients with non-dialysis chronic kidney disease. [PDF]

Ren Fail
Lin SC, Su IM, Lee CJ, Lai YH, Hsu BG.
europepmc   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Successful Revascularization of Chronic Total Occlusions in Patients With Chronic Thromboembolic Pulmonary Disease

Catheterization and Cardiovascular Interventions, Volume 107, Issue 7, Page 2323-2334, June 1, 2026.
ABSTRACT Background Chronic thromboembolic pulmonary disease (CTEPD) leads to chronic total occlusions (CTOs) of the pulmonary arteries in a minority of patients. Treatment of CTOs with balloon pulmonary angioplasty (BPA) may substantially improve patient hemodynamics but presents unique technical challenges and has previously been associated with a ...
Elliot J. Stein, Peter J. Leary, Lauren N. Carlozzi, Samuel G. Rayner, Zachary L. Steinberg   +4 more
wiley   +1 more source

Endothelin-1 induces Zfp36 family RNA-binding proteins and restrains cytokine and chemokine production in reactive astrocytes. [PDF]

J Biol Chem
Koyama Y, Nishiuma A, Takahashi N, Izumikawa E, Hamada C, Izumi Y, Hishinuma S, Michinaga S.   +7 more
europepmc   +1 more source

Survival Improvement With Steroid Use for Pulmonary Veno‐Occlusive Disease With the Aid of Pulmonary Vasodilators and Tyrosine‐Kinase Inhibitor, a Retrospective Study

Clinical Cardiology, Volume 49, Issue 6, June 2026.
This study aimed to assess the efficacy of steroid treatment with pulmonary vasodilators and tyrosine kinase inhibitors in patients with Pulmonary VenoOcclusive Disease (PVOD). Kaplan‐Meier curve showed that survival of PVOD patients with PSL (PRS) was significantly better with Log rank test (p = 0.01) than without PSL (PNS).
Mayumi Finger, Kaori Takeuchi, Hanako Kikuchi, Ayumi Goda, Takumi Inami, Yuichi Tamura, Masaharu Kataoka, Toru Satoh   +7 more
wiley   +1 more source

In silico prioritisation of EDN1 missense variants identifies mature endothelin-1 substitutions with predicted receptor-binding effects. [PDF]

BMC Genomics
Sivakumar R, Arul Senghor KA, Vinodhini VM, Ramkumar KM.   +3 more
europepmc   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Nuclear gasdermin E drives endothelin-1-induced metastatic progression independently of the pyroptosis. [PDF]

Cell Death Dis
Roman C, Caprara V, Tocci P, Sacconi A, Blandino G, Bagnato A, Sestito R.   +6 more
europepmc   +1 more source