Results 201 to 210 of about 21,304,051 (308)

Nanoparticles in Vascular Dementia: Advantages and Challenges

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu, JiaLi Hu, Yueming qiu, Huaying Wang, Chunxiao Shen, Ziying Liu, Yiting He, Xuefei Du, Xiaorong Zhang   +8 more
wiley   +1 more source

Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling. [PDF]

Int J Biol Sci
Huang J, Zhang X, Yao Z, Zhang Y, Huang D, Liu Y, Hou FF, Liu Y, Li L.   +8 more
europepmc   +1 more source

Pharmacokinetics and Neuroprotective Efficacy of Poly‐Arginine Peptide R18D in Sprague Dawley Rats Subjected to Transient Intraluminal Filament Middle Cerebral Artery Occlusion Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni, Stuart K. Gribble, Meghan G. Thomas, Ayelet Weksler, Lena Finkelstein, Lena Fishtein, Dimitry Kovalchuk, Gilad Maximov, Avital Schauder, Keren Kigel‐Zur, Sigal Meilin   +10 more
wiley   +1 more source

Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer. [PDF]

Oncol Res
Yang R, Yuan D, Liang C, Zhu S, Huang J, Zhang Y, He W, Li Q, Zhang H.   +8 more
europepmc   +1 more source

Heart–Lung Interactions in Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review considers heart–lung interactions in pulmonary hypertension due to heart failure with preserved ejection fraction across scales, including organ, tissue, and cell scales. Key knowledge gaps in preclinical disease models, tools for clinical phenotyping, and underlying biological mechanisms are identified for future studies.
Pratima Prabala, Farhan Raza, Naomi C. Chesler   +2 more
wiley   +1 more source

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension. [PDF]

Open Vet J
Cahyono A, Irwanto, Rahman MA, Widjiati W.   +3 more
europepmc   +1 more source

Leptin in Obesity‐Related Heart Failure: Pathophysiological Mechanisms and Therapeutic Implications

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Obesity‐associated adipose tissue dysfunction leads to hyperleptinemia and altered leptin signaling. Through Ob‐Rb/LepR‐mediated pathways, leptin may contribute to neurohormonal activation, endothelial dysfunction, inflammation, oxidative stress, and myocardial remodeling.
Xuemin Li, Weiguo Wang, Yibo Zhang, Pengfei Ding, Xuewen Li   +4 more
wiley   +1 more source

Endothelin-1 upregulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human periodontal ligament cells-an <i>in vitro</i> study. [PDF]

J Orthod Sci
Unmanatakoon S, Suttamanatwong S.
europepmc   +1 more source

Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
In patients with pulmonary vascular diseases (PAH and CTEPH), supplemental oxygen (FiO2 0.3), compared to room air (FiO2 0.21) improved peak exercise capacity (peak V̇O2), peak sustainable exercise (V̇O2 at GET), and V̇O2 kinetics and the onset of exercise.
Shir Kadosh, Yael Baidats, Andrew M. Jones, Daryl Wilkerson, Ariela Velner, Ronen Reuveny, Michael J. Segel   +6 more
wiley   +1 more source

Decreased Endothelin-1 bioavailability impairs aggressiveness of gallbladder cancer cells. [PDF]

Biol Res
Vidal-Vidal J, Brown-Brown D, Quilaqueo-Millaqueo N, Peña-Münzenmayer G, Spichiger C, Quezada-Monrás C, Salazar-Onfray F, Tapia JC, Niechi I.   +8 more
europepmc   +1 more source