Results 271 to 280 of about 21,304,051 (308)

Nociceptive sensitization by endothelin-1

Brain Research Reviews, 2009
The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by subcutaneously administered ET-1, and report evidence of ET-1's ability to sensitize distant regions of the body ...
Hans, Guy, Schmidt, Brian L., Strichartz, Gary   +2 more
openaire   +3 more sources

Synthesis and degradation of endothelin-1

Canadian Journal of Physiology and Pharmacology, 2003
The endothelin-converting enzyme (ECE) is the main enzyme responsible for the genesis of the potent pressor peptide endothelin-1 (ET-1). It is suggested that the ECE is pivotal in the genesis of ET-1, considering that the knockout of both genes generates the same lethal developments during the embryonic stage.
P, D'Orléans-Juste, M, Plante, J C, Honoré, E, Carrier, J, Labonté   +4 more
openaire   +2 more sources

Endothelin-1 and myocardial preconditioning

American Heart Journal, 1996
This study attempted to define the role of endothelin (ET) in preconditioning. We previously showed that ET Is produced during myocardial ischemia and reperfusion. Because both preconditioning and ET act through protein kinase C, ET could play a role in preconditioning.
J M, Erikson, C E, Velasco
openaire   +2 more sources

Fluorescence studies of endothelin-1

Neurochemistry International, 1991
Fluorescence measurements and singlet singlet energy transfer experiments on endothelin-1 provide information on the conformation of this peptide in dilute aqueous solution. The tyrosine fluorescence quantum yield in the absence of transfer (in [Phe(21)]endothelin-1) is relatively large (?(tyr) = 0.39), indicating the side-chain is oriented away from ...
openaire   +2 more sources

Endothelin-1 in luteal tissue

Molecular and Cellular Endocrinology, 1991
The aim of this study was to immunologically and biologically detect endothelin-1 (ET-1) in rat corpora lutea (CL). Recently, we established a highly sensitive and specific sandwich-enzyme immunoassay (EIA) for ET-1. Using this assay, the presence of ET-1 was investigated in superovulated ovaries, induced with pregnant mare's serum gonadotropin (PMSG ...
S, Usuki, N, Suzuki, H, Matsumoto, M, Yanagisawa, T, Masaki   +4 more
openaire   +2 more sources

Is Endothelin-1 a Mediator in Asthma?

American journal of respiratory and critical care medicine, 1996
Abstract There is a growing understanding of the effects and potential pathophysiological role of the ETs in asthma and several of the criteria required to strongly implicate ET-1 as a mediator in this disease have been fulfilled. However, some of the information is preliminary, equivocal and requires confirmation.
D W, Hay, P J, Henry, R G, Goldie
openaire   +2 more sources

The control of endothelin-1 secretion

General Pharmacology: The Vascular System, 1994
1. The human endothelin-1 (ET-1) gene, which is located on chromosome 6, contains cis-regulatory elements in the 5'-flanking region including the TPA-responsive element, nuclear factor 1 binding element and GATA motif. 2. The expression of preproendothelin-1 (PPET-1) mRNA is regulated by a mechanism involving receptor mediated mobilization of ...
K, Tasaka, K, Kitazumi
openaire   +2 more sources

Intrarenal endothelin-1 and hypertension

American Journal of Kidney Diseases, 2000
NDOTHELIN-1 (ET-1) is a 21-amino acid peptide with an order of magnitude greater vasoconstrictive potency than any known endogenous compound. Since its discovery one decade ago, more than 1,500 publications have examined the role of endothelins in the development and maintenance of primary and secondary hypertension.
openaire   +3 more sources

Endothelin-1 and the Aortic Valve

Current Vascular Pharmacology, 2005
The aortic valve is a complex structure, the function of which is fundamental to sustain life. Previously believed to be an inert structure that merely opens in response to the forward flow of blood out of the left ventricle, it is now established that it is a sophisticated structure with specific biological properties.
openaire   +2 more sources

Endothelin-1

2013
Karen A. Fagan, Natalie N. Bauer, Ivan F. McMurtry   +2 more
openaire   +2 more sources