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Journal of Cardiovascular Pharmacology, 1993
Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls).
U, Myhre +3 more
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Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls).
U, Myhre +3 more
openaire +2 more sources
Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat
Life Sciences, 1994Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ET-1 of i.v. and i.r.a.
K, Fujita +5 more
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Endothelin-1 and the Adrenal Gland
Journal of Cardiovascular Pharmacology, 2000Compelling evidence indicates an important role of endothelin (ET)-1 and its receptor subtypes A and B (ET(A) and ET(B)) in the regulation of secretion and growth of the human adrenal gland. ET-1, which is expressed both at the mRNA and at the peptide level in the adrenal cortex, directly stimulates aldosterone secretion in different species, both in ...
ROSSI, GIANPAOLO +3 more
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Endothelin-1 and big endothelin-1 in NIDDM patients with and without microangiopathy
Diabetes Research and Clinical Practice, 1994To examine a possible role for endothelin-1 in the pathophysiology of diabetic microangiopathy, we measured plasma levels of endothelin-1 and big endothelin-1, a precursor peptide of endothelin-1, in 33 untreated patients with non-insulin-dependent diabetes mellitus.
K, Kamoi, M, Ishibashi, T, Yamaji
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Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat
Biochemical and Biophysical Research Communications, 1991We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to ...
D M, Pollock, T J, Opgenorth
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Endothelin-1 and tumour development
European Journal of Surgical Oncology (EJSO), 1998There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes.
E H, Asham, M, Loizidou, I, Taylor
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Endothelin-1 and Angiogenesis in Cancer
Current Vascular Pharmacology, 2005Tumours require oxygenation, nutrition and a route for dissemination. This necessitates the development of new vessels or angiogenesis. High levels of new vessel development are indicators of poor prognosis in cancer; they also provide new avenues of anti-tumour therapy.
Jonathan, Knowles +2 more
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Endothelin-1-induced nociception
Life Sciences, 1991Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg). The ED50 values (95% confidence intervals) were 39.3 (16.5-80.2) ng and 1.5 (0.8-4.9) ng, respectively.
R B, Raffa +3 more
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