Results 341 to 350 of about 24,309,158 (381)

Nociceptive sensitization by endothelin-1

Brain Research Reviews, 2009
The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by subcutaneously administered ET-1, and report evidence of ET-1's ability to sensitize distant regions of the body ...
Hans, Guy, Schmidt, Brian L., Strichartz, Gary   +2 more
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Endothelin-1 and myocardial preconditioning

American Heart Journal, 1996
This study attempted to define the role of endothelin (ET) in preconditioning. We previously showed that ET Is produced during myocardial ischemia and reperfusion. Because both preconditioning and ET act through protein kinase C, ET could play a role in preconditioning.
J M, Erikson, C E, Velasco
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Endothelin-1 and Human Platelets

Current Vascular Pharmacology, 2005
There is conflicting evidence regarding the effect of endothelin-1 (ET-1) on platelets. Some studies show that ET-1 activates platelets, others show platelet inhibition with ET-1 and some studies did not detect an effect of ET-1. These conflicting results may be due to complex interactions between platelet ET(A) and ET(B) receptors. ET-1 antagonism may
I Anita, Jagroop, Stella S, Daskalopoulou, Dimitri P, Mikhailidis   +2 more
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Endothelin-1 in luteal tissue

Molecular and Cellular Endocrinology, 1991
The aim of this study was to immunologically and biologically detect endothelin-1 (ET-1) in rat corpora lutea (CL). Recently, we established a highly sensitive and specific sandwich-enzyme immunoassay (EIA) for ET-1. Using this assay, the presence of ET-1 was investigated in superovulated ovaries, induced with pregnant mare's serum gonadotropin (PMSG ...
S, Usuki, N, Suzuki, H, Matsumoto, M, Yanagisawa, T, Masaki   +4 more
openaire   +2 more sources

Endothelin-1 and big endothelin-1 increase in human endometrium during menstruation

American Journal of Obstetrics and Gynecology, 1995
Although the physiologic and pathologic roles of endothelin-1 in reproduction have been investigated, little is known about human uterine tissue levels. We studied the levels of immunoreactive endothelin-1 and immunoreactive big endothelin-1 in human endometrium and myometrium during each menstrual phase.Materials were obtained at hysterectomy ...
H, Ohbuchi, K, Nagai, M, Yamaguchi, T, Ikenoue, N, Mori, K, Kitamura, S, Araki, K, Toshimori   +7 more
openaire   +2 more sources

Fluorescence studies of endothelin-1

Neurochemistry International, 1991
Fluorescence measurements and singlet singlet energy transfer experiments on endothelin-1 provide information on the conformation of this peptide in dilute aqueous solution. The tyrosine fluorescence quantum yield in the absence of transfer (in [Phe(21)]endothelin-1) is relatively large (?(tyr) = 0.39), indicating the side-chain is oriented away from ...
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Micelle Formation of Endothelin-1

Journal of Cardiovascular Pharmacology, 1991
Circular dichroism of endothelin-1 synthesized through a continuous flow process reveals, when dissolved in water, a strong concentration dependence of the spectrum. Furthermore, the general feature of the spectrum rules out the possibility of the existence of any alpha and beta structures.
R, Bennes, B, Calas, P E, Chabrier, F, Heitz   +3 more
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Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat

Life Sciences, 1994
Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ET-1 of i.v. and i.r.a.
K, Fujita, Y, Matsumura, S, Kita, K, Hisaki, M, Takaoka, S, Morimoto   +5 more
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Endothelins 1 and 3 and Big Endothelin-1 Contract Isolated Human Placental Veins

Journal of Cardiovascular Pharmacology, 1993
Experiments were designed to investigate the reactivity of vascular smooth muscle to endothelins (ETs) in veins taken from human placentas immediately after delivery. The placental veins were cut into rings and suspended between two stirrups in conventional organ chambers (filled with aerated, modified Krebs-Ringer bicarbonate solution) for isometric ...
Vanhoutte, PM, Mombouli, JV, Le, SQ, Wasserstrum, N   +3 more
openaire   +3 more sources

Intrarenal endothelin-1 and hypertension

American Journal of Kidney Diseases, 2000
NDOTHELIN-1 (ET-1) is a 21-amino acid peptide with an order of magnitude greater vasoconstrictive potency than any known endogenous compound. Since its discovery one decade ago, more than 1,500 publications have examined the role of endothelins in the development and maintenance of primary and secondary hypertension.
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