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Endothelin-1: Biosynthesis, Signaling and Vasoreactivity.
Advances in Pharmacology, 2016Endothelin-1 (ET-1) is an extremely potent vasoconstrictor peptide originally isolated from endothelial cells. Its synthesis, mainly regulated at the gene transcription level, involves processing of a precursor by a furin-type proprotein convertase to an inactive intermediate, big ET-1.
M. Houde +2 more
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Journal of Cardiovascular Pharmacology, 1993
Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls).
C. Risoe +3 more
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Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls).
C. Risoe +3 more
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JAMA: The Journal of the American Medical Association, 1990
To the Editor.— Endothelin-1 is a novel 21-residue vasoconstrictor peptide produced by vascular endothelial cells. 1 It may play important roles in the pathogenesis of hypertension 2 and has been shown recently to be a potent mitogen for vascular smooth-muscle cells.
Fumiaki Marumo +6 more
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To the Editor.— Endothelin-1 is a novel 21-residue vasoconstrictor peptide produced by vascular endothelial cells. 1 It may play important roles in the pathogenesis of hypertension 2 and has been shown recently to be a potent mitogen for vascular smooth-muscle cells.
Fumiaki Marumo +6 more
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Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat
Life Sciences, 1994Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ET-1 of i.v. and i.r.a.
Katsuya Fujita +5 more
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Endothelin-1 and the Adrenal Gland
Journal of Cardiovascular Pharmacology, 2000Compelling evidence indicates an important role of endothelin (ET)-1 and its receptor subtypes A and B (ET(A) and ET(B)) in the regulation of secretion and growth of the human adrenal gland. ET-1, which is expressed both at the mRNA and at the peptide level in the adrenal cortex, directly stimulates aldosterone secretion in different species, both in ...
ROSSI, GIANPAOLO +3 more
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Endothelin-1 and big endothelin-1 in NIDDM patients with and without microangiopathy
Diabetes Research and Clinical Practice, 1994To examine a possible role for endothelin-1 in the pathophysiology of diabetic microangiopathy, we measured plasma levels of endothelin-1 and big endothelin-1, a precursor peptide of endothelin-1, in 33 untreated patients with non-insulin-dependent diabetes mellitus.
Miyuki Ishibashi +2 more
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Nociceptive sensitization by endothelin-1
Brain Research Reviews, 2009The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by subcutaneously administered ET-1, and report evidence of ET-1's ability to sensitize distant regions of the body ...
Hans, Guy +2 more
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Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat
Biochemical and Biophysical Research Communications, 1991We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to ...
Terry J. Opgenorth, David M. Pollock
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Endothelin-1 and tumour development
European Journal of Surgical Oncology (EJSO), 1998There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes.
Irving Taylor +2 more
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Intrarenal endothelin-1 and hypertension
American Journal of Kidney Diseases, 2000NDOTHELIN-1 (ET-1) is a 21-amino acid peptide with an order of magnitude greater vasoconstrictive potency than any known endogenous compound. Since its discovery one decade ago, more than 1,500 publications have examined the role of endothelins in the development and maintenance of primary and secondary hypertension.
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