Results 351 to 360 of about 23,747,035 (396)

Endothelin-1 and myocardial preconditioning

American Heart Journal, 1996
This study attempted to define the role of endothelin (ET) in preconditioning. We previously showed that ET Is produced during myocardial ischemia and reperfusion. Because both preconditioning and ET act through protein kinase C, ET could play a role in preconditioning.
Carlos E. Velasco, John M. Erikson
openaire   +3 more sources

Endothelin-1 and Human Platelets

Current Vascular Pharmacology, 2005
There is conflicting evidence regarding the effect of endothelin-1 (ET-1) on platelets. Some studies show that ET-1 activates platelets, others show platelet inhibition with ET-1 and some studies did not detect an effect of ET-1. These conflicting results may be due to complex interactions between platelet ET(A) and ET(B) receptors. ET-1 antagonism may
Stella S. Daskalopoulou, Dimitri P. Mikhailidis, I. Anita Jagroop   +2 more
openaire   +3 more sources

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

Annals of Internal Medicine, 1991
OBJECTIVE To explore the role of endothelin-1, a potent endothelial-derived vasoconstrictor peptide, in pulmonary hypertension, by measuring its concentration in arterial and venous plasma. DESIGN A survey, case series study.
D. Stewart, R. Levy, P. Cernacek, D. Langleben   +3 more
semanticscholar   +1 more source

The control of endothelin-1 secretion

General Pharmacology: The Vascular System, 1994
1. The human endothelin-1 (ET-1) gene, which is located on chromosome 6, contains cis-regulatory elements in the 5'-flanking region including the TPA-responsive element, nuclear factor 1 binding element and GATA motif. 2. The expression of preproendothelin-1 (PPET-1) mRNA is regulated by a mechanism involving receptor mediated mobilization of ...
Kazuhiro Kitazumi, Kenji Tasaka
openaire   +3 more sources

Fluorescence studies of endothelin-1

Neurochemistry International, 1991
Fluorescence measurements and singlet singlet energy transfer experiments on endothelin-1 provide information on the conformation of this peptide in dilute aqueous solution. The tyrosine fluorescence quantum yield in the absence of transfer (in [Phe(21)]endothelin-1) is relatively large (?(tyr) = 0.39), indicating the side-chain is oriented away from ...
openaire   +3 more sources

Endothelin-1-induced nociception

Life Sciences, 1991
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg). The ED50 values (95% confidence intervals) were 39.3 (16.5-80.2) ng and 1.5 (0.8-4.9) ng, respectively.
Rebecca P. Martinez, Robert B. Raffa, James J. Schupsky, Henry I. Jacoby   +3 more
openaire   +3 more sources

The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011
Nitric oxide (NO) and endothelin-1 (ET-1) are natural counterparts in vascular function, and it is becoming increasingly clear that an imbalance between these two mediators is a characteristic of endothelial dysfunction and is important in the ...
Stephane L. Bourque, S. Davidge, M. Adams   +2 more
semanticscholar   +1 more source

Endothelin-1 and Angiogenesis in Cancer

Current Vascular Pharmacology, 2005
Tumours require oxygenation, nutrition and a route for dissemination. This necessitates the development of new vessels or angiogenesis. High levels of new vessel development are indicators of poor prognosis in cancer; they also provide new avenues of anti-tumour therapy.
Marilena Loizidou, Irving Taylor, Jonathan C. Knowles   +2 more
openaire   +3 more sources

Synthesis and degradation of endothelin-1

Canadian Journal of Physiology and Pharmacology, 2003
The endothelin-converting enzyme (ECE) is the main enzyme responsible for the genesis of the potent pressor peptide endothelin-1 (ET-1). It is suggested that the ECE is pivotal in the genesis of ET-1, considering that the knockout of both genes generates the same lethal developments during the embryonic stage.
P, D'Orléans-Juste, M, Plante, J C, Honoré, E, Carrier, J, Labonté   +4 more
openaire   +3 more sources

Endothelin-1 in luteal tissue

Molecular and Cellular Endocrinology, 1991
The aim of this study was to immunologically and biologically detect endothelin-1 (ET-1) in rat corpora lutea (CL). Recently, we established a highly sensitive and specific sandwich-enzyme immunoassay (EIA) for ET-1. Using this assay, the presence of ET-1 was investigated in superovulated ovaries, induced with pregnant mare's serum gonadotropin (PMSG ...
Tomoh Masaki, Masashi Yanagisawa, Hirokazu Matsumoto, Satoshi Usuki, Nobuhiro Suzuki   +4 more
openaire   +3 more sources