Results 61 to 70 of about 21,304,051 (308)

Relevância da formação de endotelina -1(1-31) na mediação do efeito nociceptivo da big endotelina-1 em camundongos: [dissertação] [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Farmacologia.The nociceptive effects of Endothelin-1 (ET) are well-known. This peptide is synthesized by cleavage of Big ET-1 by
Somensi, Amélia Regina
core  

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source

The effect and mechanism of endothelin-1-induced intracellular free calcium in human lung adenocarcinoma cells SPC-A1

Chinese Journal of Lung Cancer, 2008
Background and objective Endothelin-1 (ET-1) is a potent mitogen involved in cell growth in human lung adenocarcinoma cells SPC-A1. The increase in intracellular free calcium ([Ca2+]i) plays a great role in this process.
Juan ZHOU, Weimin ZHANG, Qianjun YE, Gang JIA   +3 more
doaj  

Membrane depolarization is required for pressure-dependent pulmonary arterial tone but not enhanced vasoconstriction to endothelin-1 following chronic hypoxia

Pulmonary Circulation, 2020
Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary ...
Charles E Norton, Nikki L Jernigan, Benjimen R Walker, Thomas C Resta   +3 more
doaj   +1 more source

Inhibition of ENaC by Endothelin-1 [PDF]

, 2015
The amiloride-sensitive epithelial Na(+) channel (ENaC) is a key player in the regulation of Na(+) homeostasis. Its functional activity is under continuous control by a variety of signaling molecules, including bioactive peptides of endothelin family.
Andrey, Sorokin, Alexander, Staruschenko
openaire   +2 more sources

Expression profile of endothelin 1 and its receptor endothelin receptor A in papillary thyroid carcinoma and their correlations with clinicopathologic characteristics

, 2014
The endothelin axis is a group of signaling molecules and their receptors that have been implicated in vascularization of cancers, with their expression being observed to change in different cancer types.
Ariana, Armin, Salajegheh, Ali, Gopalan, Vinod, Lam, Alfred King-Yin, Irani, Soussan, Lam, Alfred, Smith, Robert, Smith, Robert Anthony, Smith, Robert A.   +8 more
core   +1 more source

Endothelin-based markers for endothelial dysfunction in chemotherapy-induced cardiotoxicity

, 2023
Current cardiac biomarkers, troponins and brain natriuretic peptide, are primarily used to assist in the diagnosis or exclusion of myocardial damage and congestive heart failure, respectively.
Zahid Pranjol (17177719), Gabrielle Boutin (17648496), Jale Yuzugulen (16289075)   +2 more
core   +1 more source

Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test). A prospective study. [PDF]

PLoS ONE, 2017
To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients.28 septic patients (8 female, 20 male, age range 35-80y) were
Magnus F Kaffarnik, Navid Ahmadi, Johan F Lock, Tilo Wuensch, Johann Pratschke, Martin Stockmann, Maciej Malinowski   +6 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

The role of the biomarker and the genetic polymorphism of endothelin-1 in pulmonary arterial hypertension among Egyptians

Egyptian Journal of Chest Disease and Tuberculosis, 2012
Study objective: This study analyses for the first time endothelin-1 (ET-1) level, and gene polymorphisms for endothelin-1 (EDN1 gene) in patients with pulmonary arterial hypertension (PAH) in Egypt. Design: Cross-sectional study.
Emad Ibrahim, Abeer Kassem, Nermin Zakaria   +2 more
doaj   +1 more source