Results 51 to 60 of about 21,304,051 (308)

Endothelin-1 and osteoblastic metastasis [PDF]

Proceedings of the National Academy of Sciences, 2003
When cancer metastasizes to distant sites, it essentially forms an army of occupation. Just as the presence of an army of occupation alters the behavior of the preexisting resident population, the resident host cells react in a variety of ways to the presence of the metastatic cancer cells.
openaire   +2 more sources

Endothelin-1_max and curve fits.

, 2019
Endothelin-1max and curve fits.
Karin Warfvinge (407987), Simon T. Christensen (6585647), Sara E. Johansson (4543459), Kristian A. Haanes (293542), Aneta Radziwon-Balicka (390291), Lars Edvinsson (54728)   +5 more
core   +1 more source

Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells

, 2020
Objective: The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB ...
Muhammed Yayla, Bilen, Arzu, Yayla, Muhammed, Bayraktutan, Zafer, Zafer Bayraktutan, Irfan Cinar, Cinar, Irfan, Çelik, Muhammet, Muhammet Celik, Arzu Bilen   +9 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Arrhythmogenic action of endothelin-1 [PDF]

Cardiovascular Research, 2000
Dear Editor, It was highly interesting to read the ‘Letter to the Editor’ by Duru et al. [1] regarding the arrhythmogenic action of endothelin-1 (ET-1). ET-1 is supposed to act as a paracrine hormone released due to stretch or myocardial ischaemia in vivo. ET-1 prolonged action potential duration with early afterdepolarization (EAD) formation in right
B, Merkely, O, Kiss, H, Vágó, E, Zima, T, Szabó, L, Gellér   +5 more
openaire   +2 more sources

Response to endothelin-1 in arteries from humnan colorectal tumours: role of endothelin receptors

, 2008
To examine the reaction of tumour arteries to endothelin-1, we obtained arteries supplying blood flow to colorectal tumours from patients, as well as mesenteric arteries supplying the normal colon tissue from the same patients and mesenteric arteries ...
Narvaez, Raul, Ferrero Herrero, Eduardo, Fernández, Nuria, Monge, Luis, Dieguez, Godofredo, Salcedo, Adely, Labalde Martínez, María, Hidalgo Pascual, Manuel, García Villalón, Ángel Luis   +8 more
core   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Endothelin-1 Role in Human Eye: A Review

Journal of Ophthalmology, 2010
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Serena Salvatore, Enzo Maria Vingolo
doaj   +1 more source

Role of endothelin-1 in hypertension [PDF]

Current Hypertension Reports, 2003
Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is overexpressed in the vasculature in different models of hypertension, such as deoxycorticosterone acetate-salt rats, Dahl salt-sensitive rats, and stroke-prone spontaneously hypertensive rats. Moreover, patients with moderate to severe hypertension present increased vascular
Marc, Iglarz, Ernesto L, Schiffrin
openaire   +2 more sources