Results 171 to 180 of about 304,614 (388)
Effects of an Endothelin-A Receptor Antagonist in a Porcine Model of Pulmonary Injury Induced by Oxygen and Inhaled Nitric Oxide [PDF]
, 1999 William E. Truog +3 more
openalex +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink +4 more
wiley +1 more source
Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
PROTEOMICS, EarlyView.
Paul Perco +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims To evaluate whether type 2 diabetes status modifies the efficacy and safety of combining zibotentan (zibo), a selective endothelin receptor antagonist, and dapagliflozin (dapa) compared to placebo plus dapagliflozin in individuals with chronic kidney disease (CKD).
Victor Wasehuus +7 more
wiley +1 more source
The Effects of Endothelin Receptor Antagonist on Hemodynamic and Respiratory Mechanics in Experimental Acute Pulmonary Thromboembolism [PDF]
, 2000 Ji Hyun Lee +9 more
openalex +1 more source
Endothelin Inhibition as a Biologic Target for Treating Hypertension [PDF]
, 2017 Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, thereby inducing vasoconstriction. Although plasma levels are not consistently elevated in hypertension, there is evidence that endothelin has an important
Brunner, Hans R.
core
WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution
The FEBS Journal, EarlyView.WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert +16 more
wiley +1 more source
Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet. [PDF]
Clin Pharmacol Ther, 2021 Gueneau de Mussy P +8 more
europepmc +1 more source
Pathogenesis of Melasma Explained
International Journal of Dermatology, EarlyView.Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley +1 more source