Results 1 to 10 of about 33,284 (165)

Endothelin-1 and Vasomotor Tone Following Cardioplegic Ischemia/Reperfusion and Cardiopulmonary Bypass [PDF]

Cells
Endothelin-1 is a potent regulator of vasomotor tone and promotes endothelium-dependent vasoconstriction of vascular smooth muscle. Dysregulated vasomotor tone is a hallmark of microvascular pathology following cardiac surgery involving cardioplegia and ...
Shawn Kant, Frank Sellke, Jun Feng
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The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders [PDF]

Gastroenterology Review
The gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells.
Arjun Singh, Rajvir Singh
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Structural basis of peptide recognition and activation of endothelin receptors

Nature Communications, 2023
Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.
Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang   +12 more
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Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. [PDF]

PLoS ONE, 2017
BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role.
Gry Freja Skovsted, Lars Schack Kruse, Lukas Adrian Berchtold, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson   +5 more
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Endothelin‐receptor interactions [PDF]

FEBS Letters, 1993
The mechanism of action of endothelin‐receptor interactions was studied, using radioligand binding assays and SDS‐PAGE, to investigate the possibility of disulfide interchange. Electrophoretic analysis suggested involvement of disulfide bond(s) in the receptor‐ligand complex.
Spinella, Michael J., Kottke, Rebecca, Magazine, Harold I., Healy, Matthew S., Catena, John A., Wilken, Philip, Andersen, Thomas T.   +6 more
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Affinity labelling of endothelin receptor and characterization of solubilized endothelin–endothelin‐receptor complex [PDF]

European Journal of Biochemistry, 1990
Chick cardiac membranes were affinity labelled by cross‐linking to membrane‐bound 125I‐endothelin‐1 with disuccinimidyl tartarate. SDS/PAGE and autoradiographic analysis of the 125I‐endothelin‐1‐labelled material in the presence or absence of 2‐mercaptoethanol revealed one major labelled band, corresponding to a molecular mass of 53 kDa, whose ...
H, Miyazaki, M, Kondoh, H, Watanabe, Y, Masuda, K, Murakami, M, Takahashi, M, Yanagisawa, S, Kimura, K, Goto, T, Masaki   +9 more
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Endothelin Receptors and Pain [PDF]

The Journal of Pain, 2009
The endogenous endothelin (ET) peptides participate in a remarkable variety of pain-relatedprocesses. Pain that is elevated by inflammation, by skin incision, by cancer, during a Sickle Cell Disease crisis and by treatments that mimic neuropathic and inflammatory pain and are all reduced by local administration of antagonists of endothelin receptors ...
Khodorova, Alla, Montmayeur, Jean-Pierre, Strichartz, Gary   +2 more
openaire   +3 more sources

High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

Frontiers in Cardiovascular Medicine, 2021
Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic valve disease in diabetes.
Sergiu Cecoltan, Letitia Ciortan, Razvan D. Macarie, Mihaela Vadana, Andreea C. Mihaila, Monica Tucureanu, Mihaela-Loredana Vlad, Ionel Droc, Mihaela Gherghiceanu, Agneta Simionescu, Agneta Simionescu, Dan Teodor Simionescu, Dan Teodor Simionescu, Elena Butoi, Ileana Manduteanu   +14 more
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Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going

Biology, 2022
Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous ...
Andreas Haryono, Risa Ramadhiani, Gusty Rizky Teguh Ryanto, Noriaki Emoto   +3 more
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Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach

Journal of Pharmacological Sciences, 2003
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura, Shoshiro Okada, Kunihiko Yokotani   +2 more
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