Clazosentan Affects Temporal Profile of Endothelin-A Expression in Macro- and Microcirculation after Subarachnoid Hemorrhage [PDF]
Neurologia Medico-ChirurgicaSubarachnoid hemorrhage is a life-threatening cerebrovascular event, and cerebral vasospasm remains a major cause of poor neurological outcomes. Clazosentan, an endothelin-A receptor antagonist, has been recently approved in Japan to reduce post ...
Yuyuan ZHENG +11 more
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Endothelium-derived endothelin-1 mediates sickle cell nephropathy [PDF]
FunctionSickle cell nephropathy (SCN) significantly shortens the life expectancy of patients with sickle cell disease (SCD). We previously reported that endothelin-1 (ET-1) and endothelin A receptor (ETA) are upregulated in SCN, and ETA antagonism mitigates SCN ...
Malgorzata Kasztan +6 more
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The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders [PDF]
Gastroenterology ReviewThe gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells.
Arjun Singh, Rajvir Singh
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Bosentan, a drug used in the treatment of pulmonary hypertension, can prevent development of osteoporosis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods.Materials and Methods: Rats were divided into 4 groups of 8 rats each: one control (Sham), one osteoporosis only (OP), and ...
Duygu Köse +6 more
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Endocan, ET-1, and ETAR Expression Profiles in Unicystic Ameloblastoma, Multicystic Ameloblastoma, and Ameloblastic Carcinoma [PDF]
Middle East Journal of Cancer, 2019 Background: Odontogenic lesions range from simple cysts to benign tumors and carcinomas. Unicystic ameloblastoma is a monocystic lesion and a less aggressive tumor compared to multicystic ameloblastoma.
Soussan Irani, Zhaleh Mohsenifar
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Endothelin‐receptor interactions [PDF]
FEBS Letters, 1993 The mechanism of action of endothelin‐receptor interactions was studied, using radioligand binding assays and SDS‐PAGE, to investigate the possibility of disulfide interchange. Electrophoretic analysis suggested involvement of disulfide bond(s) in the receptor‐ligand complex.
Spinella, Michael J. +6 more
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Archives of Medical Science, 2022 Introduction Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension Material and methods We studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in
Pratishtha Mehra +4 more
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Affinity labelling of endothelin receptor and characterization of solubilized endothelin–endothelin‐receptor complex [PDF]
European Journal of Biochemistry, 1990 Chick cardiac membranes were affinity labelled by cross‐linking to membrane‐bound 125I‐endothelin‐1 with disuccinimidyl tartarate. SDS/PAGE and autoradiographic analysis of the 125I‐endothelin‐1‐labelled material in the presence or absence of 2‐mercaptoethanol revealed one major labelled band, corresponding to a molecular mass of 53 kDa, whose ...
H, Miyazaki +9 more
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Genetic interactions between neurofibromin and endothelin receptor B in mice. [PDF]
PLoS ONE, 2013 When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose.
Mugdha Deo +2 more
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Endothelin Receptors and Pain [PDF]
The Journal of Pain, 2009 The endogenous endothelin (ET) peptides participate in a remarkable variety of pain-relatedprocesses. Pain that is elevated by inflammation, by skin incision, by cancer, during a Sickle Cell Disease crisis and by treatments that mimic neuropathic and inflammatory pain and are all reduced by local administration of antagonists of endothelin receptors ...
Khodorova, Alla +2 more
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