Results 21 to 30 of about 55,630 (278)

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

BMC Cardiovascular Disorders, 2008
Background Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a ...
Edvinsson Lars, Gesslein Bodil, Wackenfors Angelica, Gustafsson Lotta, Nilsson David, Paulsson Per, Ingemansson Richard, Malmsjö Malin   +7 more
doaj   +1 more source

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Clinical, Cosmetic and Investigational Dermatology, 2023
Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN, Miot HA, Grassi TF, Dias-Melício LA, Santos L, Espósito ACC   +5 more
doaj  

Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion

BMC Nephrology, 2012
Background Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been extensively utilized in clinical ...
Stuart Deborah, Rees Sara, Woodward Stephanie K, Koesters Robert, Strait Kevin A, Kohan Donald E   +5 more
doaj   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Johnston, F., Maguire, J.J., Maguire, Janet J., Seed, Alison, Hanka J. de Voogd, Essers, H., Janet J. Maguire, Kuc, R.E., de Voogd, H.J., Kuc, Rhoda E., Seed, A., McMurray, J.J.V., Davenport, Anthony P., Hillier, Christopher, Rhoda E. Kuc, Anthony P. Davenport, Hillier, C., Hans Essers, Davenport, A.P., Alison Seed, Johnston, Fiona, John McMurray, Christopher Hillier, McMurray, John, Fiona Johnston, Essers, Hans, de Voogd, Hanka J.   +26 more
core   +1 more source

Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger [PDF]

, 1991
Endothelin, a 21-amino acid vasoactive peptide, is among the most potent positively inotropic agents yet described in mammalian heart. Having demonstrated that endothelin's inotropic effect is due, in part, to an apparent sensitization of cardiac ...
Smith, T. W., Krämer, Bernhard K., Kelly, R. A.   +2 more
core   +1 more source

Evaluation of the Expression Levels of Endothelin-1 and its Receptor (ETAR) in Dental Lamina during Different Stages of Development of Human Fetal Teeth

پزشکی بالینی ابن سینا, 2021
Background and Objective: Due to the significant importance of the teeth in mastication, speech, and aesthetics, it is necessary to identify all involved genes in the tooth development. Therefore, this study aimed to evaluate the role of endothelin-1 and
Soussan Irani, Shohreh Alimohammadi, Tahmineh Najafian   +2 more
doaj  

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. [PDF]

PLoS ONE, 2017
BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role.
Gry Freja Skovsted, Lars Schack Kruse, Lukas Adrian Berchtold, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson   +5 more
doaj   +1 more source

EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding [PDF]

Journal of Pharmacy and Pharmacology, 2011
AbstractBackground and objectiveThe magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ETA or ETB receptors can be limited by apparent compensation mediated by the unblocked receptor. While the mechanism underlying this functionally defined interaction, or ‘cross-talk’, is not clear, binding studies suggest an ...
Robert M, Rapoport, Mario, Zuccarello
openaire   +2 more sources

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

Neurobiology of Disease, 2014
The endothelin system is implicated in various human and animal glaucomas. Targeting the endothelin system has great promise as a treatment for human glaucoma, but the cell types involved and the exact mechanisms of action are not clearly elucidated ...
Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John   +6 more
doaj   +1 more source