Results 11 to 20 of about 55,630 (278)

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

Respiratory Research, 2011
Background Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Brandes Ralf P, Janssen Wiebke, Cornitescu Teodora, Sydykov Akylbek, Dahal Bhola K, Luitel Himal, Kojonazarov Baktybek, Kosanovic Djuro, Davie Neil, Ghofrani Hossein A, Weissmann Norbert, Grimminger Friedrich, Seeger Werner, Schermuly Ralph T   +13 more
doaj   +2 more sources

Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes

Vascular Health and Risk Management, 2009
Nikolaos Östlund Papadogeorgos, Mattias Bengtsson, Majid KalaniKarolinska Institute, Department of Clinical Sciences, Department of Cardiology, Danderyd Hospital, Stockholm, SwedenBackground: Endothelin-1 may be involved in the development of ...
Nikolaos Östlund Papadogeorgos, Mattias Bengtsson, Majid Kalani   +2 more
doaj   +1 more source

Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension

Vascular Health and Risk Management, 2008
M Kathryn Steiner1, Ioana R Preston21Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; 2Pulmonary Critical Care and Sleep Division, Department of Medicine, Tufts Medical Center, Boston, MA, USAAbstract:
M Kathryn Steiner, Ioana R Preston
doaj   +1 more source

Immunohistochemical Eexpression of Endothelin A Receptor in Dysplastic Oral Mucosa [PDF]

Journal of Kerman University of Medical Sciences, 2020
Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM).
Taymaz Shirali, hamid abbaszadeh, Forough Foroughi, hemmat Gholinia   +3 more
doaj   +1 more source

Treatment of IgA nephropathy; focus on reducing proteinuria by endothelin A receptor antagonists [PDF]

Journal of Nephropathology
IgA nephropathy (IgAN) is the most frequent primary glomerulonephritis throughout world and a leading cause of chronic renal failure across with end-stage kidney failure.
Elham Ahmadipour, Hamid Nasri
doaj   +1 more source

Endothelin Receptors and Their Antagonists

Seminars in Nephrology, 2015
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
Maguire, Janet J, Davenport, Anthony P
openaire   +3 more sources

Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]

, 1998
In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Carter, ND, YF Zhang, ND Carter, Kasaki, JC, Jeffrey, S, Jeffery, S, S Jeffery, Burchill, SA, Kaski, JC, JC Kaski, Zhang, YF, PA Berry, SA Burchill, Berry, PA   +13 more
core   +1 more source

Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors. [PDF]

PLoS ONE, 2016
Injury to the eye or retina triggers Müller cells, the major glia cell of the retina, to dedifferentiate and proliferate. In some species they attain retinal progenitor properties and have the capacity to generate new neurons. The epidermal growth factor
Mohammad Harun-Or-Rashid, Dardan Konjusha, Caridad Galindo-Romero, Finn Hallböök   +3 more
doaj   +1 more source

Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar, Elizabeth M. Daugherty, Jeffrey O. Aceves, Randee Sedaka, Ijeoma E. Obi, J. Miller Allan, Reham H. Soliman, Chunhua Jin, Carmen De Miguel, Sarah H. Lindsey, Jennifer S. Pollock, David M. Pollock   +11 more
doaj   +1 more source

Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ [PDF]

, 2023
Statement of the Problem: Enamel organ (EO) is an ectodermal derived structure, which is involved in the different aspects of tooth development. Tooth development shares the same regulatory molecules and genes expressed in other developing organs ...
Tahmineh Najafian, Shohreh Alimohammadi, Alimohammadi, S, Najafian, T, Irani, S, Soussan Irani   +5 more
core   +1 more source