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The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders [PDF]
Gastroenterology ReviewThe gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells.
Arjun Singh, Rajvir Singh
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Biomedicines, 2021 The endothelium is the single-cell monolayer that lines the entire vasculature. The endothelium has a barrier function to separate blood from organs and tissues but also has an increasingly appreciated role in anti-coagulation, vascular senescence ...
Peter J. Little +3 more
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Cells, 2023 Glioblastoma (GBM) is the most common and aggressive type of brain tumor due to its elevated recurrence following treatments. This is mainly mediated by a subpopulation of cells with stemness traits termed glioblastoma stem-like cells (GSCs), which are ...
Ignacio Niechi +17 more
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Endothelin-1 level as a predictor of hepatopulmonary syndrome in liver cirrhosis [PDF]
Medicinski Glasnik, 2020 Aim To determine the role of endothelin (ET)-1 in predicting hepatopulmonary syndrome (HPS) in patients with liver cirrhosis. Methods A cross sectional study involving 80 liver cirrhosis patients aged 18 years or older was conducted in Adam Malik ...
Darmadi, Riska Habriel Ruslie
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Computational and Structural Biotechnology Journal, 2013 Introduction: The flux of uremic toxin middle molecules through currently used hemodialysis membranes is suboptimal, mainly because of the membranes' pore architecture.
Assem Hedayat +3 more
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Brain Sciences, 2022 The rupture of an intracranial aneurysm (IA) leads to life-threatening subarachnoid hemorrhage. Aside from well-established risk factors, recently published genome-wide association studies of IA revealed the strong association of a common variant near ...
Tim Lampmann +6 more
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Gnaq and Gna11 in the Endothelin signaling pathway and melanoma
Frontiers in Genetics, 2016 In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz +1 more
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Immune Mechanisms Linking Obesity and Preeclampsia
Biomolecules, 2015 Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within ...
Frank T. Spradley +2 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and organic stenosis. It has been demonstrated that endothelin-1 (ET-1) induces pulmonary vasoconstriction through the activation of RhoA.
Koichi Sugimoto +9 more
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Endothelin-1 in systemic sclerosis
Indian Dermatology Online Journal, 2012 Introduction: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis.
Mehrdad Aghaei +7 more
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