Results 21 to 30 of about 63,830 (268)

Role of prostanoids, nitric oxide and endothelin pathways in pulmonary hypertension due to COPD

Frontiers in Medicine, 2023
Pulmonary hypertension (PH) due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 PH, with no current proven targeted therapies. Studies suggest that cigarette smoke, the most risk factor for COPD can cause vascular remodelling and
Abdullah A. Alqarni, Abdullah A. Alqarni, Abdulelah M. Aldhahir, Sara A. Alghamdi, Jaber S. Alqahtani, Rayan A. Siraj, Hassan Alwafi, Abdulkareem A. AlGarni, Abdulkareem A. AlGarni, Mansour S. Majrshi, Mansour S. Majrshi, Saad M. Alshehri, Linhua Pang   +12 more
doaj   +1 more source

Endothelin and the podocyte [PDF]

Clinical Kidney Journal, 2012
In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Barton M, Tharaux PL
openaire   +3 more sources

Roles of Astrocytic Endothelin ET_B Receptor in Traumatic Brain Injury

Cells, 2023
Traumatic brain injury (TBI) is an intracranial injury caused by accidents, falls, or sports. The production of endothelins (ETs) is increased in the injured brain.
Shotaro Michinaga, Shigeru Hishinuma, Yutaka Koyama   +2 more
doaj   +1 more source

THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS

Медицинский вестник Юга России, 2015
Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.Materials and methods: 160 railroad ...
I. S. Lutskyy, S. V. Ziablices, M. S. Kishenia, L. V. Liutykova, P. A. Chernobrivec   +4 more
doaj   +1 more source

Bosentan Does Not Affect Renal Resistive Index in Scleroderma/Systemic Sclerosis Patients

Kidney & Blood Pressure Research, 2023
Introduction: If properly evaluated, chronic kidney disease can be found in up to 50% of patients with systemic sclerosis (SSc). The renal resistive index (RRI) is a marker of intrarenal vascular resistance and can predict SSc-associated vasculopathy ...
Emma Di Poi, GianLuca Colussi, Martina Bertoni, Ivan Giovannini, Barbara Tolusso, Gian Franco Ferraccioli, Elisa Gremese, Salvatore De Vita, Giulio Romano   +8 more
doaj   +1 more source

Bosentan, a drug used in the treatment of pulmonary hypertension, can prevent development of osteoporosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods.Materials and Methods: Rats were divided into 4 groups of 8 rats each: one control (Sham), one osteoporosis only (OP), and ...
Duygu Köse, Ahmet Köse, Zekai Halıcı, Elif Çadirci, Taha Tavaci, Muhammed Gürbüz, Adem Maman   +6 more
doaj   +1 more source

Novel Treatment Paradigms: Primary IgA Nephropathy

Kidney International Reports
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Approximately 30% to 45% of patients progress to kidney failure (KF) within 20 to 25 years of diagnosis, and there has long been a lack of effective treatments.
Haresh Selvaskandan, Jonathan Barratt, Chee Kay Cheung   +2 more
doaj   +1 more source

Dynamics of endothelial function indexes in patients with post-Covid syndrome using a combination drug of ethylmethylhydroxyperidine succinate/vitamin B6

Research Results in Pharmacology, 2023
Introduction: After the COVID-19 pandemic, public healthcare has faced a new problem, the persistence of symptoms, the most significant of which is undue fatigue.
Larisa V. Mikhailova, Yana D. Belousova, Ekaterina M. Moiseeva, Alina A. Tsapkova, Natalya D. Gazatova, Alexandra R. Plotnikova, Danila G. Rudev, Svetlana A. Doktorova, Vladimir V. Rafalskiy   +8 more
doaj   +1 more source

Development of adrenal 3-dimensional spheroid cultures: potential for the treatment of adrenal insufficiency and neurodegenerative diseases [PDF]

Exploration of Endocrine and Metabolic Diseases
Aim: Regenerative and curative strategies would be desirable for neurodegenerative and adrenal diseases, and multipotent adrenal stem cells are considered as promising biological tools for this purpose.
Charlotte Steenblock, Stephanie Fliedner, Giatgen A. Spinas, Racheli Ofir, Patrick Kugelmeier, Barbara Ludwig, Nicole Bechmann   +6 more
doaj   +1 more source

Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm

Frontiers in Pharmacology, 2021
Aneurysmal subarachnoid hemorrhage (aSAH) may lead to cerebral vasospasm and is associated with significant morbidity and mortality. It represents a major unmet medical need due to few treatment options with limited efficacy. The role of endothelin-1 (ET-
Pierre-Eric Juif, Jasper Dingemanse, Mike Ufer   +2 more
doaj   +1 more source