Results 11 to 20 of about 63,830 (268)
Pharmacological Reviews, 2016 The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype. Genes encoding the peptides are present only among vertebrates.
Davenport, Anthony P +8 more
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Cellular and Molecular Life Sciences, 2010 Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was originally isolated and characterized from the culture media of aortic endothelial cells. Two other isoforms, termed endothelin-2 and endothelin-3, were subsequently identified, along with structural homologues isolated from the venom of Actractapis engaddensis known
Kawanabe, Yoshifumi, Nauli, Surya M.
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Endothelin and endothelin antagonists in chronic kidney disease [PDF]
Kidney International, 2014 The incidence and prevalence of chronic kidney disease (CKD), with diabetes and hypertension accounting for the majority of cases, is on the rise, with up to 160 million individuals worldwide predicted to be affected by 2020. Given that current treatment options, primarily targeted at the renin-angiotensin system, only modestly slow down progression to
Kohan, Donald E., Barton, Matthias
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Endothelin and menstruation [PDF]
Human Reproduction, 1996 Endothelin (ET) and its mRNA are present in human endometrium. Its expression varies across the menstrual cycle, reaching maximal levels in the pre-menstrual phase. Human endometrial epithelial cells are the major in-vitro source of ET, and its release is affected by the stage of the menstrual cycle from which the endometrium is taken and by the ...
M M, Marsh +2 more
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Bagcilar Medical Bulletin, 2020 Objective:This study aimed to determine the changes in endothelin and von Willebrand factor (vWF) serum levels during early period aneurysmal subarachnoid hemorrhage (SAH) compared to healthy individuals and to analyze them according to clinical and ...
Serkan Kitiş +2 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Coronary artery ectasia (CAE) is found in about 1% of coronary angiography and is associated with poor clinical outcomes. The prognostic value of plasma big Endothelin-1 (ET-1) in CAE remains unknown.Methods: Patients with angiographically ...
Zhongxing Cai +9 more
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Transient Mesenteric Ischemia Leads to Remodeling of Rat Mesenteric Resistance Arteries
Frontiers in Physiology, 2012 Mesenteric ischemia/reperfusion (I/R) is associated with high rates of morbidity and mortality. We studied the effect of mesenteric I/R on structural and mechanical properties of rat mesenteric resistance artery (MRA) that, once disrupted, might impact ...
Laura eCaracuel +5 more
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Endothelin and restenosis [PDF]
Cardiovascular Research, 1998 Time for primary review 31 days Percutaneous transluminal angioplasty (PTCA) was first introduced into the therapy of patients with coronary artery stenosis in the late seventies [1]. In the two decades since, this method has become standard therapy for patients suffering from all forms of coronary artery disease.
M, Kirchengast, K, Münter
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Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Revista Brasileira de Reumatologia, 2009 INTRODUÇÃO: Acometimento vascular é uma manifestação central da esclerose sistêmica (ES) e pode levar a complicações como úlceras, gangrena ou amputação de extremidades.
Henrique de Ataíde Mariz +2 more
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