Results 11 to 20 of about 91,462 (235)

Endothelin and the ischaemic heart [PDF]

, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
McCabe, C., Kane, K.A., Wainwright, C.L.
core   +9 more sources

Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger [PDF]

, 1991
Endothelin, a 21-amino acid vasoactive peptide, is among the most potent positively inotropic agents yet described in mammalian heart. Having demonstrated that endothelin's inotropic effect is due, in part, to an apparent sensitization of cardiac ...
Smith, T. W., Krämer, Bernhard K., Kelly, R. A.   +2 more
core   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Johnston, F., Maguire, J.J., Maguire, Janet J., Seed, Alison, Hanka J. de Voogd, Essers, H., Janet J. Maguire, Kuc, R.E., de Voogd, H.J., Kuc, Rhoda E., Seed, A., McMurray, J.J.V., Davenport, Anthony P., Hillier, Christopher, Rhoda E. Kuc, Anthony P. Davenport, Hillier, C., Hans Essers, Davenport, A.P., Alison Seed, Johnston, Fiona, John McMurray, Christopher Hillier, McMurray, John, Fiona Johnston, Essers, Hans, de Voogd, Hanka J.   +26 more
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Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]

, 1998
In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Carter, ND, YF Zhang, ND Carter, Kasaki, JC, Jeffrey, S, Jeffery, S, S Jeffery, Burchill, SA, Kaski, JC, JC Kaski, Zhang, YF, PA Berry, SA Burchill, Berry, PA   +13 more
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Bosentana no tratamento de úlceras de extremidades refratárias na esclerose sistêmica Bosentan in the treatment of refractory extremities ulcers in systemic sclerosis

Revista Brasileira de Reumatologia, 2009
INTRODUÇÃO: Acometimento vascular é uma manifestação central da esclerose sistêmica (ES) e pode levar a complicações como úlceras, gangrena ou amputação de extremidades.
Henrique de Ataíde Mariz, Marcelo José Uchôa Corrêa, Cristiane Kayser   +2 more
doaj   +1 more source

Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats

Biology, 2023
The ubiquitous peptide endothelin is currently under investigation as a modulatory factor of autonomic responses to acute emotional stress. Baseline plasma levels of endothelin alter blood pressure responses, but it remains unclear whether autonomic ...
Eleni-Taxiarchia Mouchtouri, Thomas Konstantinou, Panagiotis Lekkas, Alexandra Lianopoulou, Zoi Kotsaridou, Iordanis Mourouzis, Constantinos Pantos, Theofilos M. Kolettis   +7 more
doaj   +1 more source

Hemodynamic and inotropic effects of endothelin-1 in vivo [PDF]

, 1994
Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs.
Beyer, M. E., Hoffmeister, H. M., Krämer, Bernhard K., Nerz, S.   +3 more
core   +1 more source

THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS

Медицинский вестник Юга России, 2015
Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.Materials and methods: 160 railroad ...
I. S. Lutskyy, S. V. Ziablices, M. S. Kishenia, L. V. Liutykova, P. A. Chernobrivec   +4 more
doaj   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
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External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial

Clinical and Experimental Hypertension, 2023
Objective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined with EECP (acupoint-EECP) for endothelial cell function in patients ...
Meilan Lin, Xiaonv Wang, Bingbing Ye, Jun Zhang, Shuman Lin, Yiye Xu, Jianguan Zhou, Sipei Liu, Shiwei Zhou, Xiafei Guan, Yan Jin, Lei Wang   +11 more
doaj   +1 more source