Results 41 to 50 of about 63,830 (268)

Role of Endothelins [PDF]

Digestion, 1998
Accessible online at: http://BioMedNet.com/karger Hyperdynamic circulation as well as increased hepatic resistance contribute to portal hypertension in cirrhosis of the liver [1]. Hyperdynamic circulation with increased cardiac output, heart rate and plasma volume and decreased arterial blood pressure and systemic vascular resistance are characteristic
Gerbes, Alexander L., Bilzer, Manfred, Gülberg, Veit   +2 more
openaire   +2 more sources

Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature

Advanced Healthcare Materials, EarlyView.
Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest, Katherine J. Young, Isabella K. Holtz, Mark Mc Veigh, James D. West, Leon M. Bellan   +5 more
wiley   +1 more source

The level of urinary endothelin in patients with urinary reflux [PDF]

Journal of Nephropathology, 2017
Background: In different tissues, the endothelin is produced by vascular endothelium. They are potent vasoconstrictor peptides. There is a little information about the role of endothelin in reflux nephropathy.
Anoush Azarfar, Mohammad Esmaeeli, Mitra Naseri, Shapour Badiee Aval, Fatemeh Ghanee Sharbaf, Sahar Ravanshad, Yalda Ravanshad, Hassan Mehrad-Majd, Sara Molkara   +8 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea

Frontiers in Endocrinology, 2018
Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological
Jan Polak, Jan Polak, Naresh M. Punjabi, Larissa A. Shimoda   +3 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Rational pharmacotherapy of chronic heart failure with increased endothelin-1 activity: beta-adrenoblocker nebivolol place

Кардиоваскулярная терапия и профилактика, 2007
Aim. To optimize chronic heart failure (CHF) pharmacotherapy, basing on endothelin (ET) system activity, functional and cardio-hemodynamic parameters, and their dynamics in beta-adrenoblocker nebivolol therapy. Material and methods. The study included 52
L. I. Olbinskaya, Yu. I. Naymann
doaj  

The Effect of Autologous Dendritic Cell Therapy on Renal Perfusion in Diabetic Kidney Disease: Analysis of Doppler Ultrasound and Angiogenesis Biomarkers

Diseases
Background: Diabetes mellitus (DM) is a global health challenge with a severe health burden. Approximately 40% of diabetic patients develop diabetic kidney disease (DKD), leading to kidney failure.
Ardianto Pramono, Jonny, Djuwita Adi Wahyono, Aditya Pratama Lokeswara, Enda Cindylosa Sitepu, Ermi Girsang, Terawan Agus Putranto   +6 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Endothelins and carcinogenesis

Postępy Higieny i Medycyny Doświadczalnej, 2016
Endothelins are a family of four endogenous peptides (ET-1, ET-2, ET-3, ET-4) secreted primarily in an inactive form by the endothelium. They are activated with the participation of converting enzyme. Numerous studies have described their pleiotropic biological activity.
Jacek, Olender, Ewa, Nowakowska-Zajdel, Katarzyna, Walkiewicz, Małgorzata, Muc-Wierzgoń   +3 more
openaire   +2 more sources