Results 41 to 50 of about 91,462 (235)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Rational pharmacotherapy of chronic heart failure with increased endothelin-1 activity: beta-adrenoblocker nebivolol place

Кардиоваскулярная терапия и профилактика, 2007
Aim. To optimize chronic heart failure (CHF) pharmacotherapy, basing on endothelin (ET) system activity, functional and cardio-hemodynamic parameters, and their dynamics in beta-adrenoblocker nebivolol therapy. Material and methods. The study included 52
L. I. Olbinskaya, Yu. I. Naymann
doaj  

Drug discovery opportunities at the endothelin B receptor-related orphan G protein-coupled receptors, GPR37 and GPR37L1

Frontiers in Pharmacology, 2015
Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery.
Nicola J Smith, Nicola J Smith
doaj   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

Frontiers in Cellular Neuroscience
Microglial cells are highly specialized cells of the central nervous system (CNS) that play dual roles in neuroprotection, but can also promote inflammation and neurodegeneration.
Yaritza Inostroza-Nieves, Shakira Bou, José Alvarado, Diego Capo-Ruiz, Diego Capo-Ruiz, Jessica Garcia, Jean P. Moliere, Claudia P. Arenas   +7 more
doaj   +1 more source

Effect of endothelin-1 on baroreflexes and the cardiovascular action of clonidine in conscious rabbits.

Frontiers in Physiology, 2016
We studied the influence of pretreatment with endothelin 1 on cardiac baroreflexes and on the effect of clonidine on blood pressure and heart rate. In order to avoid the complication of the direct vasoconstrictor effects of endothelin-1, initial dose ...
Kyungjoon Lim, Maarten Van Den Buuse, Geoffrey A Head   +2 more
doaj   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

The role of endothelin in stroke: Experimental data and underlying pathophysiology

Archives of Medical Science, 2006
The role of endothelin in functional and structural changes after stroke is only partly understood: synthesis and release of the potent vasoconstrictor peptide endothelin-1 increases following ischemia and mediates the delayed hypoperfusion associated ...
Bernhard J. Schaller
doaj  

Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism

Frontiers in Endocrinology, 2015
It has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and ...
Herve eLefebvre, Herve eLefebvre, Herve eLefebvre, Celine eDuparc, Celine eDuparc, Gaetan ePrevost, Gaetan ePrevost, Gaetan ePrevost, Jerome eBertherat, Jerome eBertherat, Estelle eLouiset, Estelle eLouiset   +11 more
doaj   +1 more source