Results 51 to 60 of about 63,830 (268)

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

Frontiers in Cellular Neuroscience
Microglial cells are highly specialized cells of the central nervous system (CNS) that play dual roles in neuroprotection, but can also promote inflammation and neurodegeneration.
Yaritza Inostroza-Nieves, Shakira Bou, José Alvarado, Diego Capo-Ruiz, Diego Capo-Ruiz, Jessica Garcia, Jean P. Moliere, Claudia P. Arenas   +7 more
doaj   +1 more source

ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function

Frontiers in Aging, 2021
Aging is a primary risk factor for cardiovascular disease (CVD), which is the leading cause of death in developed countries. Globally, the population of adults over the age of 60 is expected to double by the year 2050.
Andrew V. Kuczmarski, Laura M. Welti, Kerrie L. Moreau, Kerrie L. Moreau, Megan M. Wenner   +4 more
doaj   +1 more source

The role of endothelin in stroke: Experimental data and underlying pathophysiology

Archives of Medical Science, 2006
The role of endothelin in functional and structural changes after stroke is only partly understood: synthesis and release of the potent vasoconstrictor peptide endothelin-1 increases following ischemia and mediates the delayed hypoperfusion associated ...
Bernhard J. Schaller
doaj  

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Research progress of traditional exercise therapy on vascular endothelial function in patients with hypertension

Huli yanjiu, 2020
To review effects of traditional exercise therapy on vascular endothelial function in patients with hypertension from following aspects：nitric oxide，endothelin，C⁃reactive protein，blood lipid，blood glucose，and serum inflammatory factors.The aim of this ...
FAN Weiying, ZHENG Liwei
doaj  

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source