Results 1 to 10 of about 8,768 (188)

Cardioprotective Effects of Bosentan in Rats Subjected to Lung Ischemia–Reperfusion Injury [PDF]

Medicina
Objective: This study aimed to investigate the cardioprotective effects of bosentan, an endothelin receptor antagonist, in a rat model of lung ischemia–reperfusion (I/R) injury, with a focus on myocardial tissue involvement.
Şevki Mustafa Demiröz, Ayşegül Küçük, Esra Tekin, Sibel Söylemez, Hanife Yılmaz, Şaban Cem Sezen, Muharrem Atlı, Hüseyin Demirtaş, Abdullah Özer, Yusuf Ünal, Mustafa Arslan   +10 more
doaj   +3 more sources

Bosentan Delivery via Nano Metal-Organic Framework nanoMIL-89 Restores Vascular Homeostasis in Pulmonary Arterial Hypertension [PDF]

International Journal of Nanomedicine
Mashael A Al-Badr,1,2 Hanan H Abunada,1 Richa Gill,3 Hend S Fayed,4 Ayman Al Haj Zen,4 Mohammad A Al-Ghouti,3 Md Mizanur Rahman,2 Nura A Mohamed,1 Haissam Abou-Saleh5 1Biomedical Research Center, QU Health, Qatar University, Doha, Qatar; 2Biological ...
Al-Badr MA, Abunada HH, Gill R, Fayed HS, Al Haj Zen A, Al-Ghouti MA, Rahman MM, Mohamed NA, Abou-Saleh H   +8 more
doaj   +4 more sources

Predicting Systemic and Liver Bosentan Exposure Using Physiologically‐Based Pharmacokinetic Modeling [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Bosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black‐box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure.
Miao‐Chan Huang, Julia Macente, Sofie Heylen, Chen Ning, Kristof De Vos, Neel Deferm, Pieter Annaert   +6 more
doaj   +2 more sources

Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis [PDF]

Frontiers in Pediatrics
ObjectiveTo evaluate the efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN).MethodsPubMed, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception to ...
Guanghong Li, Xiaoqun Du, Weibin Luo, Junhua Wei, Huiyi Huang   +4 more
doaj   +2 more sources

Bosentan

Reactions Weekly
Patel P, Bhardwaj A.
europepmc   +3 more sources

Bosentan monohydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C27H29N5O6S·H2O {systematic name: 4-tert-butyl-N-[6-(2-hy-droxy-eth-oxy)-5-(2-meth-oxy-phen-oxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide monohydrate], the dihedral angle between the mean planes of the pyrimidine rings is 27.0 (1)°.
Kaur, Manpreet, Jasinski, Jerry P., Keeley, Amanda C., Yathirajan, H. S., Betz, Richard, Gerber, Thomas, Butcher, Ray J.   +6 more
openaire   +4 more sources

Comparative Treatment Persistence and Adherence to Endothelin Receptor Antagonists Among Patients with Pulmonary Arterial Hypertension in Japan: A Real-World Administrative Claims Database Study

Pulmonary Therapy, 2023
Introduction Real-world data on the comparative effectiveness of endothelin receptor antagonists (ERAs; macitentan, bosentan, ambrisentan) for pulmonary arterial hypertension (PAH), particularly in Asian countries, are scarce.
Junichi Omura, Yogeshwar Makanji, Nobuhiro Tanabe, Dae Young Yu, Jin Yu Tan, Sooyeol Lim, Mahsa H. Kouhkamari, Jeremy Casorso, David Bin-Chia Wu, Paul Bloomfield   +9 more
doaj   +1 more source

D-optimal Design for Preparation and Optimization of Fast Dissolving Bosentan Nanosuspension [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: Bosentan is a drug currently taken orally for the treatment of pulmonary arterialhypertension. However, the water solubility of bosentan is very low, resulting in lowbioavailability.
Elham Ghasemian, Parisa Motaghian, Alireza Vatanara   +2 more
doaj   +1 more source

Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized flexible molecule

Scientific Reports, 2022
A GA-guided multidimensional virtual-system coupled molecular dynamics (GA-mD-VcMD) simulation was conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein, human endothelin receptor type B (hETB).
Junichi Higo, Kota Kasahara, Gert-Jan Bekker, Benson Ma, Shun Sakuraba, Shinji Iida, Narutoshi Kamiya, Ikuo Fukuda, Hidetoshi Kono, Yoshifumi Fukunishi, Haruki Nakamura   +10 more
doaj   +1 more source

Co-inhibition of Angiotensin II Receptor and Endothelin-1 Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice

Kidney & Blood Pressure Research, 2016
Background/Aims: Both endothelin-1 (ET-1) and the renin-angiotensin system (RAS) may play important roles in renal fibrosis in the obstructed kidney.
Yoon-Kyung Chang, Hyunsu Choi, Jin Young Jeong, Ki-Ryang Na, Kang Wook Lee, Dae Eun Choi   +5 more
doaj   +1 more source