Results 21 to 30 of about 8,768 (188)

bosentan pediatrics

, 2022
bosentan pediatrics8345 NW 66 ST ...
Jefferson Buendia
core   +1 more source

Bosentan for high-risk outpatients with COVID-19 infection: a randomized, double blind, placebo-controlled trialResearch in context

EClinicalMedicine, 2023
Summary: Background: The endothelium is supposedly activated and damaged in COVID-19 because of endothelin-1 over-secretion. This study evaluates the effect of bosentan as an endothelin receptor blocker on the progression of disease in high-risk ...
Shaahin Shahbazi, Zahra Vahdat Shariatpanahi, Erfan Shahbazi   +2 more
doaj   +1 more source

Effect of bosentan in pulmonary hypertension development in systemic sclerosis patients with digital ulcers.

PLoS ONE, 2020
Systemic sclerosis is a disease where microcirculation damage is critical in their beginning and vascular complications have similar pathogenic findings. Digital ulcers are a frequent complication in systemic sclerosis patients and pulmonary hypertension
Ivan Castellví, Carmen Pilar Simeón, Monica Sarmiento, Jordi Casademont, Hèctor Corominas, Vicenç Fonollosa   +5 more
doaj   +1 more source

Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis

Drug Delivery, 2021
Background: Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a
Wenhai Fu, Wenjun He, Yuexin Li, Yangxiao Chen, Jingyi Liang, Hui Lei, Lin Fu, Yanghang Chen, Ni Ren, Qian Jiang, Yi Shen, Ran Ma, Tao Wang, Xinni Wang, Nuofu Zhang, Dakai Xiao, Chunli Liu   +16 more
doaj   +1 more source

Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project

Frontiers in Pharmacology, 2022
Introduction: Quantitative information on disposition of maternal medicines in human milk remains a major knowledge gap. This case report presents the clinical and pharmacokinetic data of a single mother-infant pair exposed to bosentan and sildenafil for
Nina Nauwelaerts, Michael Ceulemans, Michael Ceulemans, Michael Ceulemans, Neel Deferm, An Eerdekens, Bart Lammens, Yeghig Armoudjian, Kristel Van Calsteren, Kristel Van Calsteren, Karel Allegaert, Karel Allegaert, Karel Allegaert, Karel Allegaert, Loes de Vries, Pieter Annaert, Pieter Annaert, Anne Smits, Anne Smits, Anne Smits   +19 more
doaj   +1 more source

Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far

Hematology Reports, 2011
Pulmonary arterial hypertension is an infrequent but nevertheless serious life-threatening severe complication of HIV infection. It can be treated with bosentan and oral anticoagulants.
José Antonio Morales-Molina, Juan Enrique Martínez-de la Plata, Olivia Urquízar-Rodríguez, María Angustias Molina-Arrebola   +3 more
doaj   +1 more source

Distinct ETA receptor binding mode of macitentan as determined by site directed mutagenesis. [PDF]

PLoS ONE, 2014
The competitive endothelin receptor antagonists (ERA) bosentan and ambrisentan, which have long been approved for the treatment of pulmonary arterial hypertension, are characterized by very short (1 min) occupancy half-lives at the ET(A) receptor.
John Gatfield, Celia Mueller Grandjean, Daniel Bur, Martin H Bolli, Oliver Nayler   +4 more
doaj   +1 more source

Spectroscopic analysis of bosentan in biological samples after a liquid-liquid microextraction [PDF]

BioImpacts, 2015
Introduction: Microextraction processes with UV-Vis measurement have been developed and validated for analysis of bosentan in biological samples. Methods: In this work, liquid–liquid microextraction procedures (DLLME & USAEME) were employed for cleanup ...
Sanaz Sajedi-Amin, Karim Assadpour-Zeynali, Vahid Panahi-Azar, Abbas Kebriaeezadeh, Maryam Khoubnasabjafari, Khlalil Ansarin, Vahid Jouyban-Gharamaleki, Abolghasem Jouyban   +7 more
doaj   +1 more source

Association of CYP2C9*2 With Bosentan‐Induced Liver Injury [PDF]

, 2013
Bosentan (Tracleer) is an endothelin receptor antagonist prescribed for the treatment of pulmonary arterial hypertension (PAH). Its use is limited by drug-induced liver injury (DILI).
McGlothlin, D, Kobashigawa, EA, Mefford, J, Le, H, Schwartz, JB, Wu, AHB, Kroetz, DL, Sodhi, J, Khojasteh, C, Halladay, J, Markova, SM, Hsueh, W‐C, Witte, JS, Zhang, C, Rettie, AE, De Marco, T, Bendjilali, N   +16 more
core   +1 more source

Bosentan

Reactions Weekly, 2006
europepmc   +3 more sources