Results 11 to 20 of about 33,352 (233)

Endothelin Receptors and Their Antagonists

Seminars in Nephrology, 2015
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
Maguire, Janet J, Davenport, Anthony P
openaire   +3 more sources

Endothelin in health and disease

Biomolecules & Biomedicine, 2004
Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3).
Emina Nakaš-Ićindić, Asija Začiragić, Almira Hadžović, Nešina Avdagić   +3 more
doaj   +1 more source

Cerebrospinal fluid from patients with subarachnoid haemorrhage and vasospasm enhances endothelin contraction in rat cerebral arteries.

PLoS ONE, 2015
IntroductionPrevious studies have suggested that cerebrospinal fluid from patients with subarachnoid hemorrhage (SAH) leads to pronounced vasoconstriction in isolated arteries.
Barbara Assenzio, Erica L Martin, Edgaras Stankevicius, Federica Civiletti, Marco Fontanella, Marco Fontanella, Riccardo Boccaletti, Maurizio Berardino, AnnaTeresa Mazzeo, Alessandro Ducati, Ulf Simonsen, Luciana Mascia   +11 more
doaj   +1 more source

Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. [PDF]

PLoS ONE, 2011
BACKGROUND: Endothelin-1 is a potent endogenous vasoconstrictor that contributes to renal microcirculatory impairment during endotoxemia and sepsis. Here we investigated if the renal circulatory and metabolic effects of endothelin during endotoxemia are ...
Johan Fenhammar, Andreas Andersson, Jakob Forestier, Eddie Weitzberg, Alf Sollevi, Hans Hjelmqvist, Robert Frithiof   +6 more
doaj   +1 more source

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease

Haematologica, 2017
Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease.
Bérengère Koehl, Pierre Nivoit, Wassim El Nemer, Olivia Lenoir, Patricia Hermand, Catia Pereira, Valentine Brousse, Léa Guyonnet, Giulia Ghinatti, Malika Benkerrou, Yves Colin, Caroline Le Van Kim, Pierre-Louis Tharaux   +12 more
doaj   +1 more source

Endothelin type A receptors mediate pain in a mouse model of sickle cell disease

Haematologica, 2018
Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease.
Brianna Marie Lutz, Shaogen Wu, Xiyao Gu, Fidelis E. Atianjoh, Zhen Li, Brandon M. Fox, David M. Pollock, Yuan-Xiang Tao   +7 more
doaj   +1 more source

Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines. [PDF]

PLoS ONE, 2016
Periodontitis is a very common oral inflammatory disease that results in the destruction of supporting connective and osseous tissues of the teeth. Although the exact etiology is still unclear, Gram-negative bacteria, especially Porphyromonas gingivalis ...
Ga-Yeon Son, Eun-Jung Bak, Ji-Hye Kim, Dong Eun Lee, Si-Mook Kang, So Yun Lee, Lin Choi, Ji Su Sun, Seul Ki Kim, Wonse Park, Baek Il Kim, Yun-Jung Yoo, Inik Chang, Dong Min Shin   +13 more
doaj   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

BMC Cardiovascular Disorders, 2008
Background Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a ...
Edvinsson Lars, Gesslein Bodil, Wackenfors Angelica, Gustafsson Lotta, Nilsson David, Paulsson Per, Ingemansson Richard, Malmsjö Malin   +7 more
doaj   +1 more source

EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding [PDF]

Journal of Pharmacy and Pharmacology, 2011
AbstractBackground and objectiveThe magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ETA or ETB receptors can be limited by apparent compensation mediated by the unblocked receptor. While the mechanism underlying this functionally defined interaction, or ‘cross-talk’, is not clear, binding studies suggest an ...
Robert M, Rapoport, Mario, Zuccarello
openaire   +2 more sources