Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.ABSTRACT Aortic dissection is a life‐threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi‐target and multi‐pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single‐cell transcriptomics and experimental validation.
Zhaomeng Wang +10 more
wiley +1 more source
Current Status of Research on Losartan in Tumour Therapy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley +1 more source
Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan. [PDF]
Clin Pharmacokinet, 2015 Sidharta PN, Treiber A, Dingemanse J.
europepmc +1 more source
Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions
Journal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi +4 more
wiley +1 more source
Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology
Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to ...
Ting Liao +4 more
wiley +1 more source
Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms
BioMed Research International, Volume 2026, Issue 1, 2026.Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder that significantly increases cardiovascular disease (CVD) risk in women. While insulin resistance and dyslipidemia are established contributors, growing evidence highlights mitochondrial dysfunction and chronic low‐grade inflammation as central drivers of cardiovascular ...
Olabimpe Caroline Badejogbin +8 more
wiley +1 more source
The efficiency of endothelin receptor antagonist bosentan for pulmonary arterial hypertension associated with congenital heart disease: A systematic review and meta-analysis. [PDF]
Medicine (Baltimore), 2018 Kuang HY +6 more
europepmc +1 more source
The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial [PDF]
, 2011 Arnar Rafnsson +5 more
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The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti +7 more
wiley +1 more source
Journal of Diabetes Research, Volume 2026, Issue 1, 2026.Diabetes substantially increases the risk of ischemic stroke through complex metabolic, inflammatory, and vascular mechanisms, yet early identification of high‐risk individuals remains challenging. This narrative review synthesizes emerging circulating and genomic biomarkers that illuminate the pathways linking diabetes and ischemic stroke and ...
Nadia Hussain +4 more
wiley +1 more source